Diagnostic Power of Lamina Cribrosa Depth and Curvature in Glaucoma
Diagnostic Power of Lamina Cribrosa Depth and Curvature in Glaucoma
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DOI：
10.1167/iovs.16-20802
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发表时间：
2017-02-01
影响因子：
4.4
通讯作者：
Mari, Jean Martial
中科院分区：
文献类型：
--
作者：
Lee, Seung Hyen;Kim, Tae-Woo;Mari, Jean Martial
目的.目的比较筛板深度（LCD）和筛板曲率（LC）对原发性开角型青光眼（POAG）和健康眼的鉴别能力。77例POAG患者的77只眼和77例年龄、性别和眼轴长度相匹配的健康受试者的77只眼被纳入研究。LCD和筛板曲率指数（LCCI）的测量在B扫描图像中获得的扫频源光学相干断层扫描在7个位置等距跨越垂直视盘直径。在LC的七个点处进行的测量的平均值被定义为平均LCD和LCCI. POAG患者的平均LCD（527.0 ± 116.4）和平均LCCI（10.97 ± 2.59）均显著高于正常对照组（P <0.001）。LCCI患者的受试者工作特征曲线下面积（AUC）显著大于LCD患者（0.921 vs.0.784，P < 0.001）。正常人和POAG患者的眼压与平均LCD和LCCI呈正相关（分别为P = 0.021和P < 0.001），与平均LCD和LCCI呈正相关（分别为P = 0.011和P < 0.001）。POAG患者中男性与平均LCCI（P = 0.013）和LCD（P = 0.008）较大相关。LCCI对POAG与健眼的鉴别能力明显优于LCD。这一发现表明，LCCI可能比LCD更好地改善青光眼管理。
PURPOSE. To compare the capability of the lamina cribrosa depth (LCD) and lamina cribrosa (LC) curvature in discriminating between eyes with primary open-angle glaucoma (POAG) and healthy eyes.METHODS. Seventy-seven eyes of 77 patients with POAG and 77 eyes of 77 healthy subjects who were matched for age, sex, and axial length were included. The LCD and lamina cribrosa curvature index (LCCI) were measured in B-scan images obtained using swept-source optical coherence tomography at seven locations spaced equidistantly across the vertical optic disc diameter. The mean values of the measurements made at seven points of the LC were defined as the average LCD and LCCI.RESULTS. The average LCD (527.0 6 116.4 vs. 413.3 6 80.4 lm, P < 0.001) and average LCCI (10.97 6 2.59 vs. 6.81 6 1.43, P < 0.001) were significantly larger in POAG eyes than in the matched healthy subjects (all seven locations, P < 0.001). The area under the receiver operating characteristic curve (AUC) was significantly larger for the LCCI than the LCD (0.921 vs. 0.784, P < 0.001). The intraocular pressure was positively associated with average LCD and LCCI in healthy subjects (P = 0.021 and P < 0.001, respectively) and POAG patients (P = 0.011 and P < 0.001, respectively). Male sex was associated with larger average LCCI (P = 0.013) and LCD (P = 0.008) in POAG.CONCLUSIONS. The LCCI had significantly better discriminating capability between POAG and healthy eyes than LCD. This finding suggests that the LCCI may serve better than the LCD for improved glaucoma management.