Hyperlipidemia: a new therapeutic target for diabetic neuropathy.
Hyperlipidemia: a new therapeutic target for diabetic neuropathy.
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DOI:
10.1111/j.1529-8027.2009.00237.x
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发表时间:
2009-12
期刊:
影响因子:
--
通讯作者:
Feldman EL
中科院分区:
文献类型:
--
作者:
Vincent AM;Hinder LM;Pop-Busui R;Feldman EL
Emerging data establish dyslipidemia as a significant contributor to the development of diabetic neuropathy. In this review we discuss how separate metabolic imbalances, including hyperglycemia and hyperlipidemia, converge on mechanisms leading to oxidative stress in dorsal root ganglia sensory neurons. We conclude with suggestions for novel therapeutic strategies to prevent or reverse diabetes-induced nerve degeneration.
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