Striking the target in Wnt-y conditions: intervening in Wnt signaling during cancer progression.
Striking the target in Wnt-y conditions: intervening in Wnt signaling during cancer progression.
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DOI：
10.1016/j.bcp.2010.03.002
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发表时间：
2010-09-01
影响因子：
5.8
通讯作者：
Weeraratna, Ashani T.
中科院分区：
文献类型：
--
作者：
Camilli, Tura C.;Weeraratna, Ashani T.
Wnt信号通路可分为经典Wnt/β-catenin通路、非经典Wnt/Ca 2+通路和平面细胞极性（PCP）通路，其中Wnt/Ca 2+通路在肿瘤发生中起重要作用。此外，越来越多的数据表明非经典和PCP途径在肿瘤进展的几个方面的重要性。最近在理解Wnt通路促进癌症进展的参与者和机制方面的进展已经导致鉴定出许多已经或可以考虑用于治疗目的的靶点。
Wnt signaling can be divided into three pathways, namely the canonical Wnt/β-catenin pathway, and the non-canonical (or heretical) Wnt/Ca2+ and planar cell polarity (PCP) pathways, the Wnt/Ca2+ pathway was shown to play a major role in cancer. Moreover, increasing data points to the importance of the non-canonical and PCP pathways in several aspects of tumor progression. The recent advances in understanding the players and mechanisms by which the Wnt pathways contribute to cancer progression have led to the identification of numerous targets that are already or could be considered for therapeutical purposes.
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影响因子：
56.9
作者：
Behrens, J;Jerchow, BA;Birchmeier, W
通讯作者：
Birchmeier, W
影响因子：
10.5
作者：
Chen, GQ;Fernandez, J;Courey, AJ
通讯作者：
Courey, AJ
影响因子：
4.2
作者：
Baptiste, DC;Fehlings, MG
通讯作者：
Fehlings, MG
DOI：
10.1023/b:jomg.0000037157.94207.33
发表时间：
2004-04-01
影响因子：
2.5
作者：
Brennan, KR;Brown, AMC
通讯作者：
Brown, AMC
影响因子：
64.5
作者：
BROWN, AMC;WILDIN, RS;VARMUS, HE
通讯作者：
VARMUS, HE