The role of the allergist in the management of eosinophilic esophagitis.
The role of the allergist in the management of eosinophilic esophagitis.
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DOI：
10.1097/mog.0000000000000746
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发表时间：
2021-07-01
影响因子：
2.5
通讯作者：
Aceves SS
中科院分区：
文献类型：
--
作者：
Woo W;Aceves SS
本综述的目的是提供当前对过敏原/抗原的作用的理解，过敏试验的使用，并阐明过敏症专科医生在嗜酸性粒细胞性食管炎（EoE）管理中的作用。EoE是一种T2免疫紊乱，是特应性进行曲的一部分。EoE患者通常并发多种过敏性疾病。最近的研究表明，与其他过敏性疾病一样，上皮屏障功能障碍在EoE的发病机制中起着关键作用。航空和食物过敏原已被确定为EoE的诱因。EoE管理包括评估和避免其诱发抗原。由于过敏个体的综合T2免疫反应，适当的EoE护理应包括控制潜在的特应性疾病。EoE是一种复杂的疾病，最好通过多学科方法进行管理。这篇综述提供了过敏症专科医生在EoE临床管理中的最新作用。
The purpose of this review is to provide the current understanding of the role of allergens/antigens, the use of allergy testing, and to elucidate the role of the allergist in the management of eosinophilic esophagitis (EoE). EoE is a T2 immune disorder that is part of the atopic march. EoE patients commonly have multiple concurrent allergic disorders. Recent studies demonstrate that, like other allergic diseases, epithelial barrier dysfunction plays a key role in EoE pathogenesis. Aero- and food allergens have been identified as EoE triggers. EoE management includes the assessment and avoidance of its instigating antigens. Due to the integrated T2 immune response in an allergic individual, proper EoE care should include the control of underlying atopic disorders. EoE is a complex disease that is optimally managed by a multidisciplinary approach. This review provides an update on the role of the allergist in the clinical management of EoE.