Tuning endothelial monolayer adhesion: a neutron reflectivity study.
Tuning endothelial monolayer adhesion: a neutron reflectivity study.
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调节内皮单层粘附：中子反射率研究。
DOI：
10.1152/ajplung.00160.2013
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Majewski,Jaroslaw
中科院分区：
文献类型：
--
作者：
Pocivavsek,Luka;Junghans,Ann;Zebda,Noureddine;Birukov,Konstantin;Majewski,Jaroslaw
Endothelial cells, master gatekeepers of the cardiovascular system, line its inner boundary from the heart to distant capillaries constantly exposed to blood flow. Interendothelial signaling and the monolayers adhesion to the underlying collagen-rich basal lamina are key in physiology and disease. Using neutron scattering, we report the first ever interfacial structure of endothelial monolayers under dynamic flow conditions mimicking the cardiovascular system. Endothelial adhesion (defined as the separation distance ℓ between the basal cell membrane and solid boundary) is explained using developed interfacial potentials and intramembrane segregation of specific adhesion proteins. Our method provides a powerful tool for the biophysical study of cellular layer adhesion strength in living tissues.
