Pilot randomized double blind placebo-controlled study of dexamphetamine for cocaine dependence
Pilot randomized double blind placebo-controlled study of dexamphetamine for cocaine dependence
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DOI：
10.1046/j.1360-0443.2003.00447.x
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发表时间：
2003-08-01
期刊：
影响因子：
6
通讯作者：
Lewis, J
中科院分区：
文献类型：
--
作者：
Shearer, J;Wodak, A;Lewis, J
Aims To establish the feasibility of conducting a placebo-controlled clinical trial of dexamphetamine replacement therapy for cocaine dependence and to obtain preliminary data.Design Double-blind randomized placebo-controlled trial.Participants Thirty cocaine-dependent injecting drug users.Intervention Subjects were assigned randomly to receive 60 mg/day dexamphetamine (n=16) or placebo (n=14) for 14 weeks.Measurements Immunoassay and mass spectrometric techniques were used to identify cocaine metabolites in urine. Subjects were screened using the Composite International Diagnostic Interview and DSM-IV The Opiate Treatment Index, Brief Symptom Inventory, Severity of Dependence Scale and visual analogue craving scales were used to collect pre- and post-self-report data.Findings Treatment retention was equivalent between groups; however, outcomes favoured the treatment group with no improvements observed in the placebo control group. The proportion of cocaine-positive urine samples detected in the treatment group declined from 94% to 56% compared to no change in the placebo group (79% positive). While the improvements were not significant between groups, within-group analysis revealed that the treatment group reduced self-reported cocaine use (P=0.02), reduced criminal activity (P=0.04), reduced cravings (P
