Isolated retinas synthesize visual pigments from tetinol congeners delivered by liposomes.
Isolated retinas synthesize visual pigments from tetinol congeners delivered by liposomes.
复制标题
分离的视网膜通过脂质体递送的四黄醇同系物合成视觉色素。
DOI：
10.1126/science.307275
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发表时间：
1978
期刊：
影响因子：
56.9
通讯作者：
GN Noll
中科院分区：
文献类型：
--
作者：
S. Uoshikami;GN Noll
沐浴在循环林格溶液中的孤立脊椎动物视网膜无法再生所有漂白的视色素。当将含有某些视黄醇同系物的二油酰卵磷脂囊泡添加到林格溶液中时，此类视网膜立即开始再生色素。漂白的灌注视网膜的视觉色素现在可以完全恢复，使分离的视网膜成为一个独立的研究单位。脂质体可以保护氧敏感的脂溶性物质并将其递送至活细胞。
Isolated vertebrate retinas bathed in circulating Ringer solution cannot regenerate all of their bleached visual pigments. When dioleoyl-lecithin vesicles containing certain retinol congeners are added to the Ringer solution, such retinas begin to regenerate pigment immediately. The visual pigment of a bleached perfused retina can now be restored fully, making the isolated retina an independent unit for study. Loposomes can protect oxygen-sensitive, lipid-soluble substances and deliver them to living cells.