Lactic acid bacteria as antigen delivery vehicles for oral immunization purposes
Lactic acid bacteria as antigen delivery vehicles for oral immunization purposes
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DOI：
10.1016/s0168-1605(98)00048-8
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发表时间：
1998-05-26
影响因子：
5.4
通讯作者：
Conway, PL
中科院分区：
文献类型：
--
作者：
Pouwels, PH;Leer, RJ;Conway, PL
在涉及大量受试者的疫苗接种计划中，与更常用的胃肠外途径相比，口服给药途径更方便。在工业化程度较低的国家使用疫苗时，这一点尤其重要。一般而言，乳酸菌，特别是乳杆菌属菌株具有多种特性，这些特性使它们成为口服疫苗接种目的的有吸引力的候选物，例如GRAS状态、佐剂特性、粘膜粘附特性和低固有免疫原性。概述了目前的研究，旨在解开的结构和性质之间的关系，乳酸杆菌和在体内定植的表面蛋白，特别是能够粘附在上皮细胞在体外的物种。其次，将讨论乳酸菌抗原提呈的最新技术水平。最后，一些初步的免疫学数据的重组乳酸菌菌株表达抗原的病原体。(C)1998年Elsevier Science B.V.
In vaccination programmes in which large numbers of subjects are involved, the oral route of administration is more convenient as compared to the more frequently used parenteral route. This is particularly relevant when vaccines are to be applied in less industrialized countries. Lactic acid bacteria in general and strains of Lactobacillus in particular have a variety of properties which make them attractive candidates for oral vaccination purposes, e.g. GRAS status, adjuvant properties, mucosal adhesive properties and low intrinsic immunogenicity. An overview is given of current research aimed at unravelling the relationship between structure and properties of surface proteins of lactobacilli and in vivo colonization, in particular of species capable of adhering to epithelial cells in vitro. Secondly, the state of the art will be discussed with respect to antigen presentation by lactic acid bacteria. Finally, some preliminary immunological data of recombinant lactic acid bacterial strains expressing antigens from pathogens will be presented. (C) 1998 Elsevier Science B.V.