Hypertension promotes islet morphological changes with vascular injury on pre-diabetic status in SHRsp rats
Hypertension promotes islet morphological changes with vascular injury on pre-diabetic status in SHRsp rats
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DOI：
10.3109/10641963.2013.804539
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发表时间：
2014-04
影响因子：
12.3
通讯作者：
M. Satoh;H. Nagasu;Yoshisuke Haruna;C. Ihoriya;Hiroyuki Kadoya;Tamaki Sasaki;N. Kashihara
中科院分区：
文献类型：
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作者：
M. Satoh;H. Nagasu;Yoshisuke Haruna;C. Ihoriya;Hiroyuki Kadoya;Tamaki Sasaki;N. Kashihara
摘要高血压患者新发糖尿病的发生率高于血压正常者，我们推测高血压通过血管损伤引起胰岛形态学改变。为了验证我们的假设，我们给自发性高血压卒中倾向（SHRsp）大鼠肼苯哒嗪或厄贝沙坦。与对照组相比，在SHRsp大鼠中观察到更大的胰岛纤维化，并且厄贝沙坦显著改善纤维化。高脂饮食可诱导SHRsp大鼠的糖耐量异常，厄贝沙坦可改善其糖耐量，而肼苯哒嗪则无此作用。我们证明了高血压大鼠胰岛的形态学变化，我们的数据表明，血管紧张素受体阻滞剂有可能防止胰岛损伤。
Abstract Hypertensive patients have a higher incidence of new-onset diabetic mellitus than normotensive subjects, and we hypothesized that hypertension induces morphological changes in islets via vascular injury. To test our hypothesis, we administrated hydralazine or irbesartan to spontaneously hypertensive stroke-prone (SHRsp) rats. A greater islet fibrosis was observed in SHRsp rats compared with controls, and irbesartan significantly ameliorated the fibrosis. High fat diet induced glucose intorelance in SHRsp rats and irbesartan but not hydralazine improved glucose torelance. We demonstrate islet morphological changes in hypertensive rats, and our data suggest that angiotensin receptor blockers have the potential to prevent islet injury.