Delta-9-tetrahydrocannabinol may palliate altered chemosensory perception in cancer patients: results of a randomized, double-blind, placebo-controlled pilot trial
Delta-9-tetrahydrocannabinol may palliate altered chemosensory perception in cancer patients: results of a randomized, double-blind, placebo-controlled pilot trial
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DOI：
10.1093/annonc/mdq727
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发表时间：
2011-09-01
影响因子：
50.5
通讯作者：
Wismer, W. V.
中科院分区：
文献类型：
--
作者：
Brisbois, T. D.;de Kock, I. H.;Wismer, W. V.
背景资料：一项试点研究（NCT 00316563），以确定δ-9-四氢大麻酚（THC）是否可以改善味觉和嗅觉本发明的目的是提供一种用于具有化学感觉改变的癌症患者的（化学感觉）感知以及食欲、热量摄入和生活质量（QOL）的方法。成人晚期癌症患者，食欲不振和化学感觉改变，从两个地点招募，并以双盲方式随机接受THC（2.5 mg，Marinol（R）; Solvay Pharma Inc.，n = 24）或安慰剂口服胶囊（n = 22），每日两次，持续18天。21例患者完成了试验。在基线和治疗后，患者完成了一个面板的患者报告的结果：味道和食欲调查，3天的食物记录，食欲和宏量营养素偏好评估，生活质量问卷调查，和interview.Results：THC和安慰剂组在基线是可比的。与安慰剂相比，THC治疗的患者报告改善（P = 0.026）和增强（P < 0.001）化学感觉感知和食物“味道更好”（P = 0.04）。与安慰剂组相比，餐前食欲（P = 0.05）和蛋白质摄入的卡路里比例增加（P = 0.008）。THC治疗的患者报告睡眠质量（P = 0.025）和放松（P = 0.045）增加。THC和安慰剂组的QOL评分和总热量摄入量均得到改善。结论：THC可能有助于缓解化学感觉改变，并改善癌症患者的食物享受。
Background: A pilot study (NCT00316563) to determine if delta-9-tetrahydrocannabinol (THC) can improve taste and smell (chemosensory) perception as well as appetite, caloric intake, and quality of life (QOL) for cancer patients with chemosensory alterations.Patients and methods: Adult advanced cancer patients, with poor appetite and chemosensory alterations, were recruited from two sites and randomized in a double-blinded manner to receive either THC (2.5 mg, Marinol(R); Solvay Pharma Inc., n = 24) or placebo oral capsules (n = 22) twice daily for 18 days. Twenty-one patients completed the trial. At baseline and posttreatment, patients completed a panel of patient-reported outcomes: Taste and Smell Survey, 3-day food record, appetite and macronutrient preference assessments, QOL questionnaire, and an interview.Results: THC and placebo groups were comparable at baseline. Compared with placebo, THC-treated patients reported improved (P = 0.026) and enhanced (P < 0.001) chemosensory perception and food 'tasted better' (P = 0.04). Premeal appetite (P = 0.05) and proportion of calories consumed as protein increased compared with placebo (P = 0.008). THC-treated patients reported increased quality of sleep (P = 0.025) and relaxation (P = 0.045). QOL scores and total caloric intake were improved in both THC and placebo groups.Conclusions: THC may be useful in the palliation of chemosensory alterations and to improve food enjoyment for cancer patients.