Catalytic enantioselective intramolecular cyclization of N-aryl diazoamides using a titanium-BINOLate complex.
Catalytic enantioselective intramolecular cyclization of N-aryl diazoamides using a titanium-BINOLate complex.
复制标题
DOI：
10.1039/c3cc49837a
复制
发表时间：
2014-02
影响因子：
4.9
通讯作者：
T. Hashimoto;Kumiko Yamamoto;K. Maruoka
中科院分区：
文献类型：
--
作者：
T. Hashimoto;Kumiko Yamamoto;K. Maruoka
本文描述的是使用手性钛(IV)-BINOLate来正式实施使用N-芳基α-重氮酰胺的催化不对称C(sp(2))-H插入。该反应很可能通过底物 α-碳上的初始不对称质子化进行，然后进行分子内亲电芳香族取代。
Described herein is the use of chiral titanium(IV)-BINOLate to formally implement catalytic asymmetric C(sp(2))-H insertion using N-aryl α-diazoamides. The reaction most likely proceeds via initial asymmetric protonation at the α-carbon of the substrate, followed by the intramolecular electrophilic aromatic substitution.