Central implants of dilute estradiol enhance the satiety effect of CCK-8.
Central implants of dilute estradiol enhance the satiety effect of CCK-8.
复制标题
稀释雌二醇的中央植入增强了 CCK-8 的饱腹感效果。
DOI：
10.1037//0735-7044.110.4.823
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发表时间：
1996
影响因子：
1.9
通讯作者：
Platania,SP
中科院分区：
文献类型：
--
作者：
Butera,PC;Xiong,M;Davis,RJ;Platania,SP
接下来的研究评估了雌二醇直接放置在不同的脑区是否可以增加雌性大鼠CCK的饱腹效力。在实验1中，雌二醇植入PVN，而不植入VMN和第三脑室，显著增强了CCK的饱腹作用（5.0 μg/kg）。在实验2中，低剂量的CCK （0.5 μg/kg）抑制雌二醇植入雌性PVN的动物的食物摄入，而在VMN或视前区植入的动物则没有。在这两个实验中，雌二醇植入PVN在2天的激素治疗期间显著降低了食物摄入量和体重。其他部位的种植体对喂养和体重没有显著影响。这些数据支持雌二醇增强CCK饱足效应的假设，提示PVN参与了CCK和雌二醇的相互作用。（PsycINFO数据库记录(c) 2016 APA，版权所有）
The following studies evaluated whether direct placement of estradiol into different brain areas could increase the satiating potency of CCK in female rats. In Experiment 1, estradiol implants in the PVN, but not in the VMN or third ventricle, significantly enhanced the satiety actions of CCK (5.0 μg/kg). In Experiment 2, a lower dose of CCK (0.5 μg/kg) suppressed food intake in females with estradiol implants in the PVN but not in animals with implants in the VMN or preoptic area. In both experiments, estradiol implants in the PVN significantly lowered food intake and body weight during the 2-day period of hormone treatment. Implants in other areas had no significant effects on feeding or body weight. These data support the hypothesis that the satiety effect of CCK is enhanced by estradiol and suggest that the PVN is involved in the interaction between CCK and estradiol.(PsycINFO Database Record (c) 2016 APA, all rights reserved)