Evaluation of gastric motility through surface electrogastrography in critically ill septic patients. Comparison of metoclopramide and domperidone effects: A pilot randomized clinical trial
Evaluation of gastric motility through surface electrogastrography in critically ill septic patients. Comparison of metoclopramide and domperidone effects: A pilot randomized clinical trial
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DOI：
10.1016/j.rgmx.2018.03.007
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发表时间：
2019-04-01
影响因子：
1.6
通讯作者：
Madrid-Silva, A. M.
中科院分区：
文献类型：
--
作者：
Mancilla Asencio, C.;Galvez-Arevalo, L. R.;Madrid-Silva, A. M.
简介和目的：危重患者表现出广泛的胃肠道运动障碍，影响消化道。我们的目的是比较两种促动力学药物对危重脓毒症患者胃电节律的影响，通过表面胃电图（EGG）测量。材料与方法：对36例诊断为感染性休克的重症监护病房（ICU）患者进行前瞻性三盲随机研究。他们随机接受甲氧氯普胺或多潘立酮治疗。在服用研究药物前后，我们评估了主导频率（DF）、随时间的百分比分布和主导力量（DP）， DP代表收缩强度。结果：所有患者均获得可靠的胃电图。与DF随时间的分布有关，64%的患者出现心律失常，平均基线DF为2.9 cpm，平均DP为56.5 μ v
Introduction and aims: Critically ill patients present with a broad spectrum of gastrointestinal motility disorders that affect the digestive tract. Our aim was to compare the effect of two prokinetic drugs on gastric electrical rhythm in critically ill septic patients, measured through surface electrogastrography (EGG).Material and methods: A prospective triple-blinded randomized study was conducted on 36 patients admitted to the intensive care unit (ICU) with the diagnosis of septic shock. They were randomized to receive metoclopramide or domperidone. We assessed dominant frequency (DF), percentage distribution over time, and dominant power (DP), which represents the strength of contraction, before and after administration of the study drugs.Results: Reliable electrogastrograms were achieved in all patients. In relation to the distribution of DF over time, 64% of patients had dysrhythmia, the mean baseline DF was 2.9 cpm, and the mean DP was 56.5 mu v After drug administration, 58% of the patients had dysrhythmia, the mean DF increased to 5.7 cpm (P