Obesity and acute lung injury.

Obesity and acute lung injury.
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DOI:
10.1016/j.ccm.2009.05.008
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发表时间:
2009-09
影响因子:
5.7
通讯作者:
O'Brien JM Jr
O'Brien JM Jr
中科院分区:
医学3区
文献类型:
--
作者:
McCallister JW;Adkins EJ;O'Brien JM Jr

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急性肺损伤(ALI)和急性呼吸窘迫综合征(ARDS)是重症监护病房(ICU)住院和机械通气的常见适应症。ALI/ARDS也消耗大量的医疗资源,是ICU患者死亡的常见原因。肥胖引起呼吸系统生理变化,可能影响ALI/ARDS患者的预后及其对治疗的反应。此外,肥胖患者的生化改变,如炎症增加和代谢改变,可能影响具有其他危险因素(如败血症)的患者发生ALI/ARDS的风险。少数关于肥胖对急性呼吸窘迫综合征(ALI/ARDS)预后影响的研究尚无定论。此外,观察到的结果可能因所提供护理的差异而存在偏差。
Acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS) are common indications for intensive care unit (ICU) admission and mechanical ventilation. ALI/ARDS also consumes significant health care resources and is a common cause of death in ICU patients. Obesity produces changes in respiratory system physiology that could affect outcomes for ALI/ARDS patients and their response to treatment. Additionally, the biochemical alterations seen in obese patients, such as increased inflammation and altered metabolism, could affect the risk of developing ALI/ARDS in patients with another risk factor (e.g. sepsis). The few studies which have examined the influence of obesity on the outcomes from ALI/ARDS are inconclusive. Furthermore, observed results could be biased by disparities in provided care.
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发表时间: 2002-04-01
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影响因子: 2.9
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