Obesity and acute lung injury.
Obesity and acute lung injury.
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DOI:
10.1016/j.ccm.2009.05.008
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发表时间:
2009-09
影响因子:
5.7
通讯作者:
O'Brien JM Jr
中科院分区:
文献类型:
--
作者:
McCallister JW;Adkins EJ;O'Brien JM Jr
Acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS) are common indications for intensive care unit (ICU) admission and mechanical ventilation. ALI/ARDS also consumes significant health care resources and is a common cause of death in ICU patients. Obesity produces changes in respiratory system physiology that could affect outcomes for ALI/ARDS patients and their response to treatment. Additionally, the biochemical alterations seen in obese patients, such as increased inflammation and altered metabolism, could affect the risk of developing ALI/ARDS in patients with another risk factor (e.g. sepsis). The few studies which have examined the influence of obesity on the outcomes from ALI/ARDS are inconclusive. Furthermore, observed results could be biased by disparities in provided care.
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