Presentation of antigens by MHC class II molecules: getting the most out of them.
Presentation of antigens by MHC class II molecules: getting the most out of them.
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DOI：
10.1016/s0161-5890(01)00069-4
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发表时间：
2001-09
影响因子：
3.6
通讯作者：
J. Villadangos
中科院分区：
文献类型：
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作者：
J. Villadangos
MHC II类分子的功能是结合来源于进入抗原呈递细胞的内吞途径的抗原的肽，并将它们展示在质膜上以供CD 4 +T细胞识别。MHC II-肽复合物的形成需要抗原和MHC II分子在内吞途径的相同隔室中汇合。在那里，抗原和MHC II分子都经历了一系列涉及蛋白酶、其他水解酶和分子伴侣的协调变化，最终产生了广泛的MHC II-肽组合。所有导致MHC II-肽复合物形成的事件都表现出相当程度的灵活性;这种缺乏严格规则的优势在于它为T细胞提供了最大量的信息，确保病原体不会被发现。
The function of MHC class II molecules is to bind peptides derived from antigens that access the endocytic route of antigen presenting cells and display them on the plasma membrane for recognition by CD4+T cells. Formation of the MHC II–peptide complexes entails the confluence of the antigens and the MHC II molecules in the same compartments of the endocytic route. There, both the antigens and the MHC II molecules undergo a series of orchestrated changes that involve proteases, other hydrolases and chaperones, culminating in the generation of a wide repertoire of MHC II–peptide combinations. All the events that lead to formation of MHC II–peptide complexes show a considerable degree of flexibility; this lack of strict rules is advantageous in that it provides T cells with the maximum amount of information, ensuring that pathogens do not go undetected.