Progressive loss of cardiac sympathetic innervation in Parkinson's disease
Progressive loss of cardiac sympathetic innervation in Parkinson's disease
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DOI：
10.1002/ana.10236
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发表时间：
2002-08-01
影响因子：
11.2
通讯作者：
Goldstein, DS
中科院分区：
文献类型：
--
作者：
Li, ST;Dendi, R;Goldstein, DS
这项研究探讨了心脏交感神经失神经支配是否随着时间的推移在帕金森病中进展。在9例无体位性低血压的患者中，6-[F-18]氟多巴正电子发射断层扫描在首次扫描后平均2年后重复。第二次扫描中6-[F-18]氟多巴衍生的放射性低于第一次扫描，左心室游离壁中为31%，间隔中为16%。在帕金森氏病中，心脏交感神经去神经支配的丧失以一种提示回死机制的丧失模式进展。
This study addressed whether cardiac sympathetic denervation progresses over time in Parkinson's disease. In 9 patients without orthostatic hypotension, 6-[F-18]fluorodopamine positron emission tomography scanning was repeated after a mean of 2 years from the first scan. 6-[F-18]fluorodopamine-derived radioactivity was less in the second scan than in the first scan, by 31% in the left ventricular free wall and 16% in the septum. In Parkinson's disease, loss of cardiac sympathetic denervation progresses in a pattern of loss suggesting a dying-back mechanism.