Does Maternal Vitamin D Deficiency Increase the Risk of Preterm Birth: A Meta-Analysis of Observational Studies.
Does Maternal Vitamin D Deficiency Increase the Risk of Preterm Birth: A Meta-Analysis of Observational Studies.
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母亲维生素D缺乏是否会增加早产的风险：一项观察性研究的荟萃分析
DOI：
10.3390/nu8050301
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发表时间：
2016-05-20
期刊：
影响因子：
5.9
通讯作者：
Luo BA
中科院分区：
文献类型：
--
作者：
Qin LL;Lu FG;Yang SH;Xu HL;Luo BA
研究人员对怀孕期间维生素D缺乏与早产（PTB）之间的关系存在分歧。因此，我们对观察性研究进行了荟萃分析，以评估这种关联。我们使用以下关键词对PubMed、MEDLINE和科克伦图书馆进行了系统性文献检索，检索截止日期为2015年8月：“维生素D”或“胆钙化醇”或“25-羟基维生素D”或“25（OH）D”与“早产”或“早产”或“PTB”或“早产”或“PTD”或“早产”。我们对10项研究的荟萃分析包括10,098名参与者，发现维生素D缺乏的孕妇（母体血清25（OH）D水平< 20 ng/mL）经历了显著增加的PTB风险（比值比（OR）= 1.29，95%置信区间（CI）：1.16，1.45），具有低异质性（I2 = 25%，p = 0.21）。敏感性分析表明，排除任何单一研究不会实质性改变整体综合效应。在亚组分析中，我们发现在前瞻性队列研究中异质性明显（I2 = 60%，p = 0.06）。总之，孕期维生素D缺乏的孕妇患PTB的风险增加。
There are disagreements among researchers about the association between vitamin D deficiency during pregnancy and preterm birth (PTB). Therefore, we conducted a meta-analysis of observational studies to evaluate this association. We performed a systematic literature search of PubMed, MEDLINE and the Cochrane Library through August 2015 with the following keywords: “vitamin D” or “cholecalciferol” or “25-hydroxyvitamin D” or “25(OH)D” in combination with “premature birth” or “preterm birth” or “PTB” or “preterm delivery” or “PTD” or “prematurity”. Our meta-analysis of 10 studies included 10,098 participants and found that pregnant women with vitamin D deficiency (maternal serum 25 (OH) D levels < 20 ng/mL) experienced a significantly increased risk of PTB (odds ratio (OR) = 1.29, 95% confidence intervals(CI): 1.16, 1.45) with low heterogeneity (I2 = 25%, p = 0.21). Sensitivity analysis showed that exclusion of any single study did not materially alter the overall combined effect. In the subgroup analyses, we found that heterogeneity was obvious in prospective cohort studies (I2 = 60%, p = 0.06). In conclusion, pregnant women with vitamin D deficiency during pregnancy have an increasing risk of PTB.