Cytotoxicity of conventional and atypical antipsychotic drugs in relation to glucose metabolism
Cytotoxicity of conventional and atypical antipsychotic drugs in relation to glucose metabolism
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DOI：
10.1016/s0006-8993(03)02351-5
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发表时间：
2003-05-02
期刊：
影响因子：
2.9
通讯作者：
Bradley, RJ
中科院分区：
文献类型：
--
作者：
Dwyer, DS;Lu, XH;Bradley, RJ
这些研究的目的是分析常规和非典型抗精神病药物的细胞毒性与其对葡萄糖代谢的影响的关系。评价了药物对PC12细胞活力的影响，PC12细胞是培养的神经元细胞的已建立模型。一般情况下，常规药物如氯丙嗪、氟奋乃静和匹莫齐特的毒性大于非典型药物如氯氮平、奎替利嗪和利培酮。奥氮平的独特之处在于它刺激该系统中的细胞增殖。药物的细胞毒性与其阻断葡萄糖转运的能力之间存在良好的相关性，尽管这种趋势有一些例外。传统的抗精神病药物也影响了葡萄糖转运蛋白在整个细胞提取物和细胞表面的表达。总的来说，数据支持这样一种观点，即许多与患者运动障碍发展相关的抗精神病药物对培养细胞具有细胞毒性。(C)2003 Elsevier Science B.V.保留所有权利。
The goal of these studies was to analyze the cytotoxicity of both the conventional and atypical antipsychotic drugs in relation to their effects on glucose metabolism. The drugs were evaluated for their effects on the viability of PC12 cells, which are an established model of neuronal cells in culture. In general, the conventional drugs, such as chlorpromazine, fluphenazine and pimozide, were more toxic than the atypical drugs, including clozapine, quetiapine and risperidone. Olanzapine was unique in that it stimulated cell proliferation in this system. There was a good correlation between the cytotoxicity of a drug and its ability to block glucose transport, although there were some exceptions to this trend. Conventional antipsychotics also affected the expression of glucose transporter proteins in whole cell extracts and at the cell surface. Overall, the data support the notion that many of the antipsychotic drugs associated with the development of movement disorders in patients are cytotoxic for cultured cells. (C) 2003 Elsevier Science B.V. All rights reserved.