Social isolation disrupts autonomic regulation of the heart and influences negative affective behaviors
Social isolation disrupts autonomic regulation of the heart and influences negative affective behaviors
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DOI：
10.1016/j.biopsych.2007.04.011
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发表时间：
2007-11-15
影响因子：
10.6
通讯作者：
Porges, Stephen W.
中科院分区：
文献类型：
--
作者：
Grippo, Angela J.;Lamb, Damon G.;Porges, Stephen W.
背景：有文献证明情感障碍（例如，抑郁症和焦虑症）和心血管疾病。慢性社会应激源可能在行为和心脏失调的发展中起机械作用。目前的研究调查行为，心脏，和自主神经反应的慢性社会应激原草原田鼠，啮齿动物物种，显示社会行为类似于human.Methods：女性草原田鼠暴露于4周的社会隔离（n = 8）或配对（对照条件; n = 7）。在隔离期间连续记录心电图参数，并在此期间和之后进行行为测试。结果：隔离诱导静息心率显着增加，心率变异性（标准差正常到正常的间隔和呼吸性窦性心律失常的幅度）减少，并夸大了心脏反应在急性居民入侵者的范例。在经过验证的操作测试中，隔离也会导致抑郁样和焦虑样行为。这些变化在响应社会隔离表现出可预测的相互关系，并介导的自主神经平衡，包括交感神经和副交感神经（迷走神经）mechanism.Conclusions的破坏：这些研究结果表明，社会隔离诱导行为，心脏和自主神经的改变后看到的其他压力和相关的心血管疾病和情感障碍。这个模型可以提供深入了解这些共同发生的条件下的机制。
Background: There is a documented association between affective disorders (e.g., depression and anxiety) and cardiovascular disease in humans. Chronic social stressors may play a mechanistic role in the development of behavioral and cardiac dysregulation. The current study investigated behavioral, cardiac, and autonomic responses to a chronic social stressor in prairie voles, a rodent species that displays social behaviors similar to humans.Methods: Female prairie voles were exposed to 4 weeks of social isolation (n = 8) or pairing (control conditions; n = 7). Electrocardiographic parameters were recorded continuously during isolation, and behavioral tests were conducted during and following this period.Results: Isolation induced a significant increase in resting heart rate, reduction in heart rate variability (standard deviation of normal-to-normal intervals and amplitude of respiratory sinus arrhythmia), and exaggerated cardiac responses during an acute resident-intruder paradigm. Isolation led also to both depression-like and anxiety-like behaviors in validated operational tests. These changes in response to social isolation showed predictable interrelations and were mediated by a disruption of autonomic balance including both sympathetic and parasympathetic (vagal) mechanisms.Conclusions: These findings indicate that social isolation induces behavioral, cardiac, and autonomic alterations related to those seen after other stressors and which are relevant to cardiovascular disease and affective disorders. This model may provide insight into the mechanisms that underlie these co-occurring conditions.