Transcranial magnetic stimulation of deep brain regions: evidence for efficacy of the H-coil
Transcranial magnetic stimulation of deep brain regions: evidence for efficacy of the H-coil
复制标题
DOI：
10.1016/j.clinph.2004.11.008
复制
发表时间：
2005-04-01
影响因子：
4.7
通讯作者：
Hallett, M
中科院分区：
文献类型：
--
作者：
Zangen, A;Roth, Y;Hallett, M
目的：用于研究和临床无创人脑磁刺激的标准线圈不能直接刺激脑深部区域。由于这些线圈引起的磁场随着深度的变化而迅速减弱，只有非常高的强度才能对大脑深层区域进行功能性刺激，这样的强度会导致不良的副作用。我们已经设计了一种基于数值模拟和幻影大脑测量的线圈，它可以刺激大脑更深的区域，被称为Hesed线圈(H-线圈)。在本研究中，我们在健康志愿者身上测试了H线圈的有效性和一些安全性方面的问题。方法：通过测量运动皮质中拇短展肌(APB)的激活阈值，将H线圈与常规的8字形线圈在6名健康志愿者中进行比较。结果：H线圈的线圈强度随距离的下降速度明显减慢。与8字形线圈相比，H线圈在5.5 cm的距离可以激活运动皮质。结论：本研究表明，H线圈可能具有脑深部刺激的能力，而不需要将强度增加到极端水平，从而在大脑皮层产生更大的刺激。意义：无创深部脑刺激的能力潜在地打开了广泛的研究和治疗应用。(C)2004年国际临床神经生理学联合会。爱思唯尔爱尔兰有限公司出版。版权所有。
Objective: Standard coils used in research and the clinic for noninvasive magnetic stimulation of the human brain are not capable of stimulating deep brain regions directly. As the fields induced by these coils decrease rapidly as a function of depth, only very high intensities would allow functional stimulation of deep brain regions and such intensities would lead to undesirable side effects. We have designed a coil based on numerical simulations and phantom brain measurements that allows stimulation of deeper brain regions, termed the Hesed coil (H-coil). In the present study we tested the efficacy and some safety aspects of the H-coil on healthy volunteers.Methods: The H-coil was compared to a regular figure-8 coil in 6 healthy volunteers by measuring thresholds for activation of the abductor pollicis brevis (APB) representation in the motor cortex as a function of distance from each of the coils.Results: The rate of decrease in the coil intensity as a function of distance is markedly slower for the H-coil. The motor cortex could be activated by the H-coil at a distance of 5.5 cm compared to 2 cm with the figure-8 coil.Conclusions: The present study indicate that the H-coil is likely to have the ability of deep brain stimulation and without the need of increasing the intensity to extreme levels that would cause a much greater stimulation in cortical regions.Significance: The ability of non-invasive deep brain stimulation potentially opens a wide range of both research and therapeutic applications. (c) 2004 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.