In Vivo Study of the Efficacy of the Essential Oil of Zanthoxylum bungeanum Pericarp in Dextran Sulfate Sodium-Induced Murine Experimental Colitis
In Vivo Study of the Efficacy of the Essential Oil of Zanthoxylum bungeanum Pericarp in Dextran Sulfate Sodium-Induced Murine Experimental Colitis
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花椒果皮精油对右旋糖酐硫酸钠诱导的小鼠实验性结肠炎疗效的体内研究
DOI：
10.1021/acs.jafc.7b01323
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发表时间：
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影响因子：
6.1
通讯作者：
Zhang Naisheng
中科院分区：
文献类型：
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作者：
Zhang Zecai;Shen Peng;Liu Jiuxi;Gu Cong;Lu Xiaojie;Li Yanxin;Liu Bo;Fu Yunhe;Cao Yongguo;Zhang Naisheng
The purpose of this study was to investigate the protective effects and mechanisms of the essential oil ofZanthoxylum bungeanumpericarp (ZBEO) on dextran sulfate sodium (DSS)-induced experimental colitis in mice. ZBEO decreased DSS-induced body weight loss, the disease activity index, colon length shortening, colonic pathological damage, and myeloperoxidase activities. The production of pro-inflammatory mediators was significantly alleviated by ZBEO. Further mechanistic analysis showed that ZBEO inhibited inflammation by regulating NF-κB and PPARγ pathways. ZBEO also inhibited NLRP3 activation in colitis in mice. Furthermore, ZBEO contributed to the maintenance of tight junction architecture by regulating the expression of zonula occludens-1 during colitis. Surprisingly, treatment with ZBEO increased levels of the commensal bacteria containingLactobacillusandBifidobacteriabut reducedEscherichia colilevels in the feces of mice. These results suggested that supplementation with ZBEO might provide a new dietary strategy for the prevention of ulcerative colitis.
