DOSAGE-SENSITIVE MODIFIERS OF DROSOPHILA-ABL TYROSINE KINASE FUNCTION - PROSPERO, A REGULATOR OF AXONAL OUTGROWTH, AND DISABLED, A NOVEL TYROSINE KINASE SUBSTRATE
DOSAGE-SENSITIVE MODIFIERS OF DROSOPHILA-ABL TYROSINE KINASE FUNCTION - PROSPERO, A REGULATOR OF AXONAL OUTGROWTH, AND DISABLED, A NOVEL TYROSINE KINASE SUBSTRATE
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DOI：
10.1101/gad.7.3.441
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发表时间：
1993-03-01
影响因子：
10.5
通讯作者：
HOFFMANN, FM
中科院分区：
文献类型：
--
作者：
GERTLER, FB;HILL, KK;HOFFMANN, FM
在果蝇abl蛋白酪氨酸激酶（PTK）缺失的情况下，残疾或繁荣的功能缺失突变对胚胎发育具有显性的表型影响。分子和遗传特征表明，这些基因的产物通过不同的机制与abl PTK相互作用。abl和prospero之间的相互作用可能是间接的，前者编码正确轴突生长所需的核蛋白。相反，disabled的产物可能是abl PTK的底物。该失能蛋白与abl共定位于轴突，其预测的氨基酸序列包含10个与abl主要自磷酸化位点相似的基序，并且该蛋白可被磷酸酪氨酸抗体识别。
In the absence of the Drosophila abl protein-tyrosine kinase (PTK), loss-of-function mutations in either disabled or prospero have dominant phenotypic effects on embryonic development. Molecular and genetic characterizations indicate that the products of these genes interact with the abl PTK by different mechanisms. The interaction between abl and prospero, which encodes a nuclear protein required for correct axonal outgrowth, is likely to be indirect. In contrast, the product of disabled may be a substrate for the abl PTK. The disabled protein is colocalized with abl in axons, its predicted amino acid sequence contains 10 motifs similar to the major autophosphorylation site of abl, and the protein is recognized by antibodies to phosphotyrosine.