CURE OF MALIGNANT-LYMPHOMA IN DOGS WITH PERIPHERAL-BLOOD STEM-CELL TRANSPLANTATION
CURE OF MALIGNANT-LYMPHOMA IN DOGS WITH PERIPHERAL-BLOOD STEM-CELL TRANSPLANTATION
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DOI：
10.1097/00007890-198607000-00004
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发表时间：
1986-07-01
期刊：
影响因子：
6.2
通讯作者：
BENSINGER, W
中科院分区：
文献类型：
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作者：
APPELBAUM, FR;DEEG, HJ;BENSINGER, W
对12只化疗缓解期自发性恶性淋巴瘤犬进行了全身照射(TBI)和自体外周血单个核细胞移植治疗。4只动物(33%)死于移植相关并发症，5只(41%)复发，3只(25%)长期无病存活。到第16天，狗的白细胞恢复到1000个/mm3，到第37天，狗不再需要输注血小板。除了血小板恢复延迟外，这些结果与之前报道的使用自体骨髓移植治疗犬淋巴瘤的结果几乎相同。因此，这项研究表明，在化疗诱导的干细胞池扩大后收集的自体外周血单核细胞可能为恶性淋巴瘤患者提供一种现实的替代自体骨髓移植的方法，因为恶性淋巴瘤患者无法获得自体骨髓。
Twelve dogs with spontaneous malignant lymphoma in chemotherapy-induced remission were treated with total-body irradiation (TBI) and transplantation of autologous peripheral blood mononuclear cells collected following chemotherapy-induced expansion of the stem cell pool. Four animals (33%) died of transplant-related complications, five (41%) relapsed, and three (25%) are long-term disease-free survivors. Recovery to 1000 white cells/mm3 occurred by day 16 and dogs no longer required platelet transfusions by day 37. With the exception of delayed platelet recovery these results are virtually identical to those previously reported using autologous bone marrow transplantation for canine lymphoma. This study therefore suggests that autologous peripheral blood mononuclear cells collected following chemotherapy-induced expansion of the stem cell pool may offer a realistic alternative to autologous marrow transplantation in patients with malignant lymphoma for whom autologous marrow is not available.