Lethal influenza infection in the absence of the natural killer cell receptor gene Ncr1
Lethal influenza infection in the absence of the natural killer cell receptor gene Ncr1
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DOI：
10.1038/ni1322
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发表时间：
2006-05-01
影响因子：
30.5
通讯作者：
Mandelboim, O
中科院分区：
文献类型：
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作者：
Gazit, R;Gruda, R;Mandelboim, O
自然杀伤细胞对病毒和肿瘤的清除是由特定的自然杀伤细胞受体介导的。为了研究主要活化自然杀伤细胞受体NCR 1（人类NKp 46）的体内功能，我们用绿色荧光蛋白报告盒替换了编码该受体（Ncr 1）的基因。在129/Sv小鼠中某些肿瘤的扩散增强，但在C57 BL/6 Ncr 1（gfp/gfp）小鼠中没有，并且流感病毒感染在129/Sv和C57 BL/6 Ncr 1（gfp/gfp）小鼠中都是致命的。通过追踪绿色荧光蛋白，我们注意到自然杀伤细胞在流感感染部位的积累。我们的研究结果表明，Ncr 1在体内根除流感病毒的关键功能。
The elimination of viruses and tumors by natural killer cells is mediated by specific natural killer cell receptors. To study the in vivo function of a principal activating natural killer cell receptor, NCR1 (NKp46 in humans), we replaced the gene encoding this receptor (Ncr1) with a green fluorescent protein reporter cassette. There was enhanced spread of certain tumors in 129/Sv but not C57BL/6 Ncr1(gfp/gfp) mice, and influenza virus infection was lethal in both 129/Sv and C57BL/6 Ncr1(gfp/gfp) mice. We noted accumulation of natural killer cells at the site of influenza infection by tracking the green fluorescent protein. Our results demonstrate a critical function for Ncr1 in the in vivo eradication of influenza virus.