Composite coating of bonelike apatite particles and collagen fibers on poly L-lactic acid formed through an accelerated biomimetic coprecipitation process
Composite coating of bonelike apatite particles and collagen fibers on poly L-lactic acid formed through an accelerated biomimetic coprecipitation process
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DOI：
10.1002/jbm.b.30356
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发表时间：
2006-05-01
影响因子：
3.4
通讯作者：
Li, JS
中科院分区：
文献类型：
--
作者：
Chen, Y;Mak, AFT;Li, JS
采用加速仿生法在聚L-乳酸（PLLA）表面共沉淀胶原和磷灰石复合涂层。孵育液中含有胶原蛋白（1 g/L）和5倍于人血浆无机离子浓度的模拟体液。通过能量色散X射线光谱、X射线衍射、傅里叶变换红外光谱和扫描电子显微镜（SEM）对24 h孵育后在PLLA膜和支架上形成的涂层进行了表征。结果表明，涂层中含有碳酸化的类骨磷灰石和胶原，其组成与天然骨相似。SEM显示亚微米骨样磷灰石颗粒与胶原纤维结合的复杂复合涂层。预期这种生物复合材料涂层可以更好地促进细胞相互作用和骨传导性。本研究为制备类骨磷灰石/胶原复合涂层提供了一种有效的方法，具有潜在的骨组织工程应用价值。(c)2006 Wiley Periodicals，Inc.
Collagen and apatite were coprecipitated as a composite coating on poly L-lactic acid (PLLA) in an accelerated biomimetic process. The incubation solution contained collagen (1 g/L) and simulated body fluid with 5 times inorganic ionic concentrations as human blood plasma. The coating formed on PLLA films and scaffolds after a 24-h incubation was characterized by using energy-dispersive X-ray spectroscopy, X-ray diffraction, Fourier transform infrared spectroscopy, and scanning electron microscopy (SEM). It was shown that the coating contained carbonated bonelike apatite and collagen, which was similar in composition to natural bone. SEM showed a complex composite coating of submicron bonelike apatite particulates combined with collagen fibrils. It is expected that such biocomposite coating may better facilitate cell interaction and osteoconductivity. This work provided an efficient process to obtain bonelike apatite/collagen composite coating, which is potentially useful in bone tissue engineering. (c) 2006 Wiley Periodicals, Inc.