Association between asthma and rhinitis according to atopic sensitization in a population-based study
Association between asthma and rhinitis according to atopic sensitization in a population-based study
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DOI：
10.1016/j.jaci.2003.10.010
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发表时间：
2004-01-01
影响因子：
14.2
通讯作者：
Neukirch, F
中科院分区：
文献类型：
--
作者：
Leynaert, N;Neukirch, C;Neukirch, F
背景资料：虽然哮喘和鼻炎经常同时发生，但这一共同并发症的原因仍存在争议。目的：我们试图评估哮喘和鼻炎的共存是否可以用共同的危险因素来解释。方法：对年轻成年人的代表性样本进行的国际横断面研究，这些年轻人完成了详细的问卷调查，并接受了肺功能检查、支气管激发试验、IgE测量，结果：在所有国家中，哮喘和支气管高反应性在鼻炎患者中的发生率均高于无鼻炎患者（OR分别为6.63，95%CI为5.44-8.08和3.02，95%CI为2.66-3.43）。74%至81%的哮喘受试者报告鼻炎，这取决于对特定过敏原的致敏性。相反，哮喘风险从无鼻炎受试者的2.0%增加到仅暴露于花粉的鼻炎受试者的6.7%，暴露于动物的鼻炎受试者的11.9%，暴露于花粉或动物的鼻炎受试者的18.8%。在调整总IgE、父母哮喘史和过敏原致敏性后，鼻炎和哮喘之间的相关性仍然显著（OR，3.41; 95%CI 2.75-4.21），表明哮喘和鼻炎的共存不仅仅是由于这两种疾病的特应性易感性。尽管根据对个别过敏原的致敏性，哮喘和鼻炎之间的关联存在一些变化，但哮喘和鼻炎之间的强关联并不能完全用共同的风险因素来解释，包括过敏症我们的研究结果与鼻炎可能增加哮喘风险的假设一致。
Background: Although asthma and rhinitis often occur together, the reason for this common comorbidity is still a matter of debate.Objective: We sought to assess whether the coexistence of asthma and rhinitis could be explained by common risk factors.Methods: International cross-sectional study of representative samples of young adults, who completed a detailed questionnaire and underwent lung function tests, bronchoprovocation challenge, IgE measurements, and skin prick tests.Results: In all countries, asthma and bronchial hyperreactivity were more frequent in subjects with rhinitis than in those without (odds ratio [OR], 6.63; 95% C1, 5.44-8.08; and OR, 3.02 95% CI, 2.66-3.43, respectively). Seventy-four percent to 81 % of subjects with asthma reported rhinitis, depending on sensitization to specific allergens. Conversely, the risk of asthma increased from 2.0% in subjects without rhinitis to 6.7% in subjects with rhinitis only when exposed to pollen, 11.9% in subjects with rhinitis when exposed to animals, and 18.8% in subjects with rhinitis either when exposed to pollen or to animals. The association between rhinitis and asthma remained significant after adjustment for total IgE, parental history of asthma, and allergen sensitization (OR, 3.41; 95% CI 2.75-4.21), suggesting that the coexistence of asthma and rhinitis is not solely due to atopic predisposition to these 2 diseases.Conclusions: Although there were some variations in the association between asthma and rhinitis according to sensitization to individual allergens, the strong association between asthma and rhinitis was not fully explained by shared risk factors, including atopy. Our findings are consistent with the hypothesis that rhinitis might increase the risk of asthma.