The Effects of Quercetin on Acute Lung Injury and Biomarkers of Inflammation and Oxidative Stress in the Rat Model of Sepsis
The Effects of Quercetin on Acute Lung Injury and Biomarkers of Inflammation and Oxidative Stress in the Rat Model of Sepsis
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DOI：
10.1007/s10753-015-0296-9
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发表时间：
2016-04-01
期刊：
影响因子：
5.1
通讯作者：
Gurel, Ahmet
中科院分区：
文献类型：
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作者：
Gerin, Fethullah;Sener, Umit;Gurel, Ahmet
实验研究表明，脓毒症可引起远隔器官损伤，但其分子机制尚未明确。本研究探讨了盲肠结扎穿孔脓毒症模型肺组织中氧化损伤和炎症反应在肺损伤中的作用，以及槲皮素、抗氧化剂和抗炎黄酮在肺组织中的作用。在本研究中，我们发现在盲肠结扎和穿刺程序之前给予单剂量槲皮素，同时显著降低YKL-40和氧化剂分子（黄嘌呤氧化酶（XO）、一氧化氮（NO）和丙二醛（MDA））的水平，增加抗氧化酶的水平。槲皮素通过降低氧化应激指标水平和提高抗氧化酶活性对急性肺损伤有保护作用。槲皮素还引起由实验性脓毒症模型诱导的氧化性肺损伤中的血清YKL-40和骨膜蛋白水平的降低。
Experimental studies indicate that sepsis causes remote organ injury although the molecular mechanism has not been clearly defined. In this report, the role of oxidative damage, and inflammation on lung injury, following sepsis model by cecal ligation and puncture, and the effects of quercetin, antioxidant, and anti-inflammatory flavonoid, in the lung tissue were investigated. In the present study, we found that administration of single-dose quercetin before cecal ligation and puncture procedure, while markedly diminishing the levels of YKL-40 and oxidant molecules (xanthine oxidase (XO), nitric oxide (NO), and malondialdehyde (MDA)), increases the antioxidant enzymes levels. Quercetin is beneficial to acute lung injury by decreasing the levels of oxidative stress markers and increasing the antioxidant enzyme activities. Quercetin also causes a decrease in the serum levels of YKL-40 and periostin in the oxidative lung injury induced by the experimental sepsis model.