Positive Correlation Between the Density of Neuropeptide Y Positive Neurons in the Amygdala and Parameters of Self-Reported Anxiety and Depression in Mesiotemporal Lobe Epilepsy Patients
Positive Correlation Between the Density of Neuropeptide Y Positive Neurons in the Amygdala and Parameters of Self-Reported Anxiety and Depression in Mesiotemporal Lobe Epilepsy Patients
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DOI：
10.1016/j.biopsych.2009.03.025
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发表时间：
2009-09-01
影响因子：
10.6
通讯作者：
Helmstaedter, Christoph
中科院分区：
文献类型：
--
作者：
Frisch, Christian;Hanke, Joachim;Helmstaedter, Christoph
背景：神经肽Y(NPY)与抑郁、焦虑和记忆有关。人NPY的表达和啮齿动物杏仁核中NPY阳性神经元的数量与焦虑和应激相关行为有关。癫痫脑中NPY表达的增加被认为代表了一种适应性机制，对抗癫痫相关的炒作兴奋。我们试图研究人类杏仁核中的NPY阳性神经元是否参与了这些过程。方法：在34例接受颞叶手术以控制癫痫发作的成年癫痫患者中，检测了杏仁基底核、外侧核和副基底核团中NPY阳性神经元的密度。细胞计数与抑郁、焦虑、生活质量、临床参数(癫痫发作和持续时间、发作频率)、抗癫痫药物、杏仁核和海马区磁共振成像体积测量相关。结果：杏仁核基底外侧区NPY阳性神经元密度与抑郁和焦虑评分呈显著正相关，与拉莫三嗪剂量呈负相关。结论：杏仁核NPY在负性情绪中起一定作用，至少在颞叶癫痫患者中，NPY可能反映了癫痫的状态过程。未发现与癫痫常见临床参数的相关性。在颞叶癫痫中，与疾病相关的NPY阳性杏仁核神经元密度降低的问题需要进一步的研究。
Background: Neuropeptide Y (NPY) has been implicated in depression, anxiety, and memory. Expression of human NPY and the number of NPY-positive neurons in the rodent amygdala correlate with anxiety and stress-related behavior. Increased NPY expression in the epileptic brain is supposed to represent an adaptive mechanism counteracting epilepsy-related hype rexcitability. We attempted to investigate whether NPY-positive neurons in the human amygdala are involved in these processes.Methods: In 34 adult epileptic patients undergoing temporal lobe surgery for seizure control, the density of NPY-positive neurons was assessed in the basal, lateral, and accessory-basal amygdala nuclei. Cell counts were related to self-reported depression, anxiety, quality of life, clinical parameters (onset and duration of epilepsy, seizure frequency), antiepileptic medication, and amygdala and hippocampal magnetic resonance imaging volumetric measures.Results: Densities of NPY-positive basolateral amygdala neurons showed significant positive correlations with depression and anxiety scores, and they were negatively correlated with lamotrigine dosage. In contrast, NPY cell counts showed no relation to clinical factors or amygdalar and hippocampal volumes.Conclusions: The results point to a role of amygdalar NPY in negative emotion and might reflect state processes at least in patients with temporal lobe epilepsy. Correlations with common clinical parameters of epilepsy were not found. The question of a disease-related reduction of the density of NPY-positive amygdalar neurons in temporal lobe epilepsy requires further investigation.