Runs of homozygosity associate with decreased risks of lung cancer in never-smoking East Asian females.
Runs of homozygosity associate with decreased risks of lung cancer in never-smoking East Asian females.
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纯合性的运行与从不吸烟的东亚女性患肺癌的风险降低相关
DOI:
10.7150/jca.22855
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发表时间:
2018
影响因子:
3.9
通讯作者:
Yang TL
中科院分区:
文献类型:
--
作者:
Chen YX;Guo Y;Dong SS;Chen XF;Chen JB;Zhang YJ;Yao S;Thynn HN;Zhi L;Yang TL
Although genome-wide association studies (GWASs) have identified some risk single-nucleotide polymorphisms in East Asian never-smoking females, the unexplained missing heritability is still required to be investigated. Runs of homozygosity (ROHs) are thought to be a type of genetic variation acting on human complex traits and diseases. We detected ROHs in 8,881 East Asian never-smoking women. The summed ROHs were used to fit a logistic regression model which noteworthily revealed a significant association between ROHs and the decreased risk of lung cancer (P < 0.05). We identified 4 common ROHs regions located at 2p22.1, which were significantly associated with decreased risk of lung cancer (P = 2.00 × 10-4 - 1.35 × 10-4). Functional annotation was conducted to investigate the regulatory function of ROHs. The common ROHs were overlapped with potential regulatory elements, such as active epigenome elements and chromatin states in lung-derived cell lines. SOS1 and ARHGEF33 were significantly up-regulated as the putative target genes of the identified ROHs in lung cancer samples according to the analysis of differently expressed genes. Our results suggest that ROHs could act as recessive contributing factors and regulatory elements to influence the risk of lung cancer in never-smoking East Asian females.
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影响因子:
3.7
作者:
Kirin M;McQuillan R;Franklin CS;Campbell H;McKeigue PM;Wilson JF
通讯作者:
Wilson JF
影响因子:
64.8
作者:
LI, N;BATZER, A;SCHLESSINGER, J
通讯作者:
SCHLESSINGER, J
影响因子:
64.8
作者:
Joshi PK;Esko T;Mattsson H;Eklund N;Gandin I;Nutile T;Jackson AU;Schurmann C;Smith AV;Zhang W;Okada Y;Stančáková A;Faul JD;Zhao W;Bartz TM;Concas MP;Franceschini N;Enroth S;Vitart V;Trompet S;Guo X;Chasman DI;O'Connel JR;Corre T;Nongmaithem SS;Chen Y;Mangino M;Ruggiero D;Traglia M;Farmaki AE;Kacprowski T;Bjonnes A;van der Spek A;Wu Y;Giri AK;Yanek LR;Wang L;Hofer E;Rietveld CA;McLeod O;Cornelis MC;Pattaro C;Verweij N;Baumbach C;Abdellaoui A;Warren HR;Vuckovic D;Mei H;Bouchard C;Perry JRB;Cappellani S;Mirza SS;Benton MC;Broeckel U;Medland SE;Lind PA;Malerba G;Drong A;Yengo L;Bielak LF;Zhi D;van der Most PJ;Shriner D;Mägi R;Hemani G;Karaderi T;Wang Z;Liu T;Demuth I;Zhao JH;Meng W;Lataniotis L;van der Laan SW;Bradfield JP;Wood AR;Bonnefond A;Ahluwalia TS;Hall LM;Salvi E;Yazar S;Carstensen L;de Haan HG;Abney M;Afzal U;Allison MA;Amin N;Asselbergs FW;Bakker SJL;Barr RG;Baumeister SE;Benjamin DJ;Bergmann S;Boerwinkle E;Bottinger EP;Campbell A;Chakravarti A;Chan Y;Chanock SJ;Chen C;Chen YI;Collins FS;Connell J;Correa A;Cupples LA;Smith GD;Davies G;Dörr M;Ehret G;Ellis SB;Feenstra B;Feitosa MF;Ford I;Fox CS;Frayling TM;Friedrich N;Geller F;Scotland G;Gillham-Nasenya I;Gottesman O;Graff M;Grodstein F;Gu C;Haley C;Hammond CJ;Harris SE;Harris TB;Hastie ND;Heard-Costa NL;Heikkilä K;Hocking LJ;Homuth G;Hottenga JJ;Huang J;Huffman JE;Hysi PG;Ikram MA;Ingelsson E;Joensuu A;Johansson Å;Jousilahti P;Jukema JW;Kähönen M;Kamatani Y;Kanoni S;Kerr SM;Khan NM;Koellinger P;Koistinen HA;Kooner MK;Kubo M;Kuusisto J;Lahti J;Launer LJ;Lea RA;Lehne B;Lehtimäki T;Liewald DCM;Lind L;Loh M;Lokki ML;London SJ;Loomis SJ;Loukola A;Lu Y;Lumley T;Lundqvist A;Männistö S;Marques-Vidal P;Masciullo C;Matchan A;Mathias RA;Matsuda K;Meigs JB;Meisinger C;Meitinger T;Menni C;Mentch FD;Mihailov E;Milani L;Montasser ME;Montgomery GW;Morrison A;Myers RH;Nadukuru R;Navarro P;Nelis M;Nieminen MS;Nolte IM;O'Connor GT;Ogunniyi A;Padmanabhan S;Palmas WR;Pankow JS;Patarcic I;Pavani F;Peyser PA;Pietilainen K;Poulter N;Prokopenko I;Ralhan S;Redmond P;Rich SS;Rissanen H;Robino A;Rose LM;Rose R;Sala C;Salako B;Salomaa V;Sarin AP;Saxena R;Schmidt H;Scott LJ;Scott WR;Sennblad B;Seshadri S;Sever P;Shrestha S;Smith BH;Smith JA;Soranzo N;Sotoodehnia N;Southam L;Stanton AV;Stathopoulou MG;Strauch K;Strawbridge RJ;Suderman MJ;Tandon N;Tang ST;Taylor KD;Tayo BO;Töglhofer AM;Tomaszewski M;Tšernikova N;Tuomilehto J;Uitterlinden AG;Vaidya D;van Hylckama Vlieg A;van Setten J;Vasankari T;Vedantam S;Vlachopoulou E;Vozzi D;Vuoksimaa E;Waldenberger M;Ware EB;Wentworth-Shields W;Whitfield JB;Wild S;Willemsen G;Yajnik CS;Yao J;Zaza G;Zhu X;Project TBJ;Salem RM;Melbye M;Bisgaard H;Samani NJ;Cusi D;Mackey DA;Cooper RS;Froguel P;Pasterkamp G;Grant SFA;Hakonarson H;Ferrucci L;Scott RA;Morris AD;Palmer CNA;Dedoussis G;Deloukas P;Bertram L;Lindenberger U;Berndt SI;Lindgren CM;Timpson NJ;Tönjes A;Munroe PB;Sørensen TIA;Rotimi CN;Arnett DK;Oldehinkel AJ;Kardia SLR;Balkau B;Gambaro G;Morris AP;Eriksson JG;Wright MJ;Martin NG;Hunt SC;Starr JM;Deary IJ;Griffiths LR;Tiemeier H;Pirastu N;Kaprio J;Wareham NJ;Pérusse L;Wilson JG;Girotto G;Caulfield MJ;Raitakari O;Boomsma DI;Gieger C;van der Harst P;Hicks AA;Kraft P;Sinisalo J;Knekt P;Johannesson M;Magnusson PKE;Hamsten A;Schmidt R;Borecki IB;Vartiainen E;Becker DM;Bharadwaj D;Mohlke KL;Boehnke M;van Duijn CM;Sanghera DK;Teumer A;Zeggini E;Metspalu A;Gasparini P;Ulivi S;Ober C;Toniolo D;Rudan I;Porteous DJ;Ciullo M;Spector TD;Hayward C;Dupuis J;Loos RJF;Wright AF;Chandak GR;Vollenweider P;Shuldiner A;Ridker PM;Rotter JI;Sattar N;Gyllensten U;North KE;Pirastu M;Psaty BM;Weir DR;Laakso M;Gudnason V;Takahashi A;Chambers JC;Kooner JS;Strachan DP;Campbell H;Hirschhorn JN;Perola M;Polašek O;Wilson JF
通讯作者:
Wilson JF
影响因子:
9.8
作者:
Gamsiz, Ece D.;Viscidi, Emma W.;Morrow, Eric M.
通讯作者:
Morrow, Eric M.
影响因子:
8.8
作者:
Pifarré A;Rosell R;Monzó M;De Anta JM;Moreno I;Sánchez JJ;Ariza A;Mate JL;Martińez E;Sánchez M
通讯作者:
Sánchez M