Results of a multicentre, randomised controlled trial of intra-arterial urokinase in the treatment of acute posterior circulation ischaemic stroke
Results of a multicentre, randomised controlled trial of intra-arterial urokinase in the treatment of acute posterior circulation ischaemic stroke
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DOI：
10.1159/000086121
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发表时间：
2005-01-01
影响因子：
2.9
通讯作者：
Donnan, GA
中科院分区：
文献类型：
--
作者：
Macleod, MR;Davis, SM;Donnan, GA
背景：基底动脉或椎动脉闭塞引起的缺血性卒中患者可出现神经系统状态的快速恶化，导致昏迷，并常导致死亡。虽然动脉内溶栓可以在这种情况下使用，但没有随机对照数据支持其安全性或有效性。方法：卒中后循环血管闭塞患者24小时内动脉内尿激酶的随机对照试验。结果：16例患者被随机分组，组间存在一定的不平衡，治疗组发生更严重的脑卒中。8例接受动脉内尿激酶治疗的患者中有4例预后良好，对照组8例患者中有1例预后良好。结论：这些结果支持需要进行大规模的研究来确定动脉内溶栓治疗急性基底动脉闭塞的疗效。版权所有(C) 2005 S. Karger AG，巴塞尔。
Background: Patients with ischaemic stroke due to occlusion of the basilar or vertebral arteries may develop a rapid deterioration in neurological status leading to coma and often to death. While intra-arterial thrombolysis may be used in this context, no randomised controlled data exist to support its safety or efficacy. Methods: Randomised controlled trial of intra-arterial urokinase within 24 h of symptom onset in patients with stroke and angiographic evidence of posterior circulation vascular occlusion. Results: Sixteen patients were randomised, and there was some imbalance between groups, with more severe strokes occurring in the treatment arm. A good outcome was observed in 4 of 8 patients who received intra-arterial urokinase compared with 1 of 8 patients in the control group. Conclusions: These results support the need for a large-scale study to establish the efficacy of intra-arterial thrombolysis for acute basilar artery occlusion. Copyright (C) 2005 S. Karger AG, Basel.