Natural selection affects frequencies of AG and GT dinucleotides at the 5′ and 3′ ends of exons
Natural selection affects frequencies of AG and GT dinucleotides at the 5′ and 3′ ends of exons
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DOI：
10.1534/genetics.167.1.543
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发表时间：
2004-05-01
期刊：
影响因子：
3.3
通讯作者：
Ruvinsky, A
中科院分区：
文献类型：
--
作者：
Eskesen, ST;Eskesen, FN;Ruvinsky, A
GT 和 AG 位于内含子 5' 和 3' 末端，对于正确剪接非常重要。预计自然选择会降低外显子 5' 和 3' 末端附近 AG 和 GT 的频率，从而防止出现隐秘剪接位点。本文提供的数据支持了这一预期。
GT and AG, located at the 5' and 3' ends of introns, are important for correct splicing. It is anticipated that natural selection decreases frequency of AG and GT near the 5' and 3' ends of exons, preventing appearance of cryptic splicing sites. The data presented in this article support the expectation.