MICRONUTRIENT STATUS AND HUMAN-IMMUNODEFICIENCY-VIRUS (HIV) INFECTION
MICRONUTRIENT STATUS AND HUMAN-IMMUNODEFICIENCY-VIRUS (HIV) INFECTION
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DOI：
10.1111/j.1749-6632.1990.tb00146.x
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发表时间：
1990-05-15
影响因子：
5.2
通讯作者：
LOURIA, D
中科院分区：
文献类型：
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作者：
BOGDEN, JD;BAKER, H;LOURIA, D
本研究通过ELISA和确证性Western印迹法调查了HIV-1血清阳性受试者的维生素、电解质和微量元素的血清浓度。在医院诊所招募了30名受试者（26名男性，4名女性）。17例被归类为轻度或重度ARC（艾滋病相关综合征），7例患有艾滋病，6例无症状。其中8人在过去6个月内体重减轻了10磅或更多。大多数（93%）对皮试抗原无反应性。具有低于正常血浆浓度的受试者的体重包括：锌-30%、钙-27%、镁-30%、胡萝卜素-31%、总胆碱-50%和抗坏血酸-27%。87%的受试者至少有一个异常低值。高于正常值的代谢物包括：叶酸-37%和肉毒碱-37%。一些血浆维生素高于正常值的受试者报告自我补充，通常是大剂量。结果表明，一个或多个异常低浓度的血浆微量营养素研究在这里可能是目前在大多数艾滋病毒血清阳性患者。
This study surveyed serum concentrations of vitamins, electrolytes, and trace elements in subjects seropositive for HIV-1 by ELISA and confirmatory Western blot. Thirty subjects (26 males, 4 females) were recruited at a hospital clinic. Seventeen were classified as having mild or severe ARC (AIDS-related complex), 7 had AIDS, and 6 were asymptomatic. Eight had experienced weight loss of 10 pounds or more in the past 6 months. Most (93%) were anergic to skin test antigens. Percentages of subjects with below normal plasma concentrations include: zinc-30%, calcium-27%, magnesium-30%, carotenes-31%, total choline-50%, and ascorbate-27%. Eighty-seven percent of the subjects had at least one abnormally low value. Percentages with above normal values include: folate-37% and carnitine-37%. Some subjects with above normal values for plasma vitamins reported self-supplementation, usually with large doses. The results suggest that one or more abnormally low concentrations of the plasma micronutrients studied here are likely to be present in the majority of HIV seropositive patients.