Eukaryotic Fe-hydrogenases - old eukaryotic heritage or adaptive acquisitions?
Eukaryotic Fe-hydrogenases - old eukaryotic heritage or adaptive acquisitions?
复制标题
DOI：
10.1042/bst0330047
复制
发表时间：
2005-02-01
影响因子：
3.9
通讯作者：
Hackstein, JHP
中科院分区：
文献类型：
--
作者：
Hackstein, JHP
所有真核生物似乎都拥有极有可能是从祖先的铁氢酶进化而来的蛋白质。这些被称为NARF或NAR的蛋白质不产生氢。值得注意的是，一小群相当不相关的单细胞厌氧菌和少数藻类拥有产生氢的铁氢酶。在大多数但不是所有生物体中，氢的产生发生在膜结合的细胞器中，即氢小体或叶绿体。而叶绿体是单系进化的，氢小体是从线粒体或类线粒体细胞器反复独立进化而来的。对各种氢小体及其氢酶的系统分析将有助于理解真核细胞的进化，并为铁氢酶的进化起源(S)提供线索。
All eukaryotes seem to possess proteins that most probably evolved from an ancestral Fe-hydrogenase. These proteins, known as NARF or Nar, do not produce hydrogen. Notably, a small group of rather unrelated unicellular anaerobes and a few algae possess Fe-hydrogenases, which produce hydrogen. In most, but not all organisms, hydrogen production occurs in membrane-bounded organelles, i.e. hydrogenosomes or plastids. Whereas plastids are monophyletic, hydrogenosomes evolved repeatedly and independently from mitochondria or mitochondria-like organelles. A systematic analysis of the various hydrogenosomes and their hydrogenases will contribute to an understanding of the evolution of the eukaryotic cell, and provide clues to the evolutionary origin(s) of the Fe-hydrogenase.