Inflammation and Atherosclerosis
Inflammation and Atherosclerosis
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DOI：
10.1007/s00059-004-2634-9
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发表时间：
2004-12
期刊：
影响因子：
1.7
通讯作者：
S. Steffens;F. Mach
中科院分区：
文献类型：
--
作者：
S. Steffens;F. Mach
目前普遍认为动脉粥样硬化是一种慢性炎症性疾病，其特征在于白细胞（单核细胞和T细胞）过度募集至炎症部位。血管损伤对心血管危险因素的反应促进内皮功能障碍，导致粘附分子表达增强和促炎细胞因子和趋化因子的分泌。这反过来又导致白细胞在动脉粥样硬化病变内的粘附、迁移和积聚。动脉粥样硬化发展中的炎症过程的最新发现提供了危险因素和动脉粥样硬化形成机制之间的重要联系。因此，研究兴趣越来越多地集中在炎症生物标志物作为预测未来临床事件风险的手段。事实上，血浆中可溶性细胞间粘附分子-1、白细胞介素-6或C反应蛋白（CRP）等分子水平升高已被证明是未来心血管风险的炎症标志物。其中，CRP已成为最强大的和可用于临床使用。未来研究的一个主要挑战是实施这些新的见解，以改善预测，预防和治疗心血管事件的策略。
It is now generally recognized that atherosclerosis is a chronic inflammatory disease, characterized by overrecruitment of leukocytes (monocytes and T-cells) to the site of inflammation. Vascular injury in response to cardiovascular risk factors promotes endothelial dysfunction, resulting in enhanced adhesion molecule expression and secretion of pro-inflammatory cytokines and chemokines. This, in turn, leads to adherence, migration and accumulation of leukocytes within atherosclerotic lesions. The recent findings on inflammatory processes involved in atherosclerosis development provide important links between risk factors and the mechanisms of atherogenesis. Thus, research interest has increasingly focused on inflammatory biomarkers as means of predicting the risk of future clinical events. Indeed, elevated plasma levels of molecules such as soluble intercellular adhesion molecule-1, interleukin-6 or C-reactive protein (CRP) have been shown to represent inflammatory markers of future cardiovascular risk. Among these, CRP has emerged as the most powerful and accessible for clinical use. A major challenge for future research is to implement these new insights in order to improve strategies for prediction, prevention and treatment of cardiovascular events.