Insight into the mechanisms and functions of spliceosomal snRNA pseudouridylation.
Insight into the mechanisms and functions of spliceosomal snRNA pseudouridylation.
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DOI：
10.4331/wjbc.v5.i4.398
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发表时间：
2014-11-26
期刊：
影响因子：
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通讯作者：
Yu, Yi-Tao
中科院分区：
文献类型：
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作者：
Adachi, Hironori;Yu, Yi-Tao
假尿苷（Pseudouridines，Psis）是存在于所有生物体的各种稳定RNA中的最丰富和高度保守的修饰核苷酸。大多数Psis聚集在对前体mRNA剪接功能重要的区域。Psi有一个额外的氢键供体，赋予RNA分子不同的特性，对RNA介导的细胞过程有显着贡献。实验数据表明，剪接体snRNA假尿苷化可以由RNA依赖性和RNA非依赖性机制催化。最近的工作还表明，假尿苷化可以诱导在新的位置在压力条件下，这表明Psi的调节作用。
Pseudouridines (Psis) are the most abundant and highly conserved modified nucleotides found in various stable RNAs of all organisms. Most Psis are clustered in regions that are functionally important for pre-mRNA splicing. Psi has an extra hydrogen bond donor that endows RNA molecules with distinct properties that contribute significantly to RNA-mediated cellular processes. Experimental data indicate that spliceosomal snRNA pseudouridylation can be catalyzed by both RNA-dependent and RNA-independent mechanisms. Recent work has also demonstrated that pseudouridylation can be induced at novel positions under stress conditions, suggesting a regulatory role for Psi.