Long-Term Surgical Outcomes of Carotid Body Tumors With Pathological Fibrosis: A Cohort Study.
Long-Term Surgical Outcomes of Carotid Body Tumors With Pathological Fibrosis: A Cohort Study.
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DOI：
10.3389/fonc.2021.684600
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发表时间：
2021
影响因子：
4.7
通讯作者：
Guo D
中科院分区：
文献类型：
--
作者：
Tang H;Jiang X;Xue S;Fu W;Tang X;Guo D
目的比较颈动脉体瘤（CBT）伴或不伴病理性纤维化的手术疗效，探讨纤维化CBT（FCBT）的相关因素。回顾性分析了2008年1月至2020年5月在我中心接受单侧CBTs的236例患者的石蜡包埋组织。根据病理特点将CBTs分为FCBT和常规CBT（CCBT）组。比较两组患者的临床资料及手术效果。236例患者中，53例FCBT，183例CCBT。与CCBT相比，FCBTs显示更高的血管浸润（24.53%），明显多形性（22.64%），颈内动脉重建（37.74%），估计失血量（559.62 cm 3）和术后神经损伤（49.06%），10年复发率（89.2%）和无主要不良事件生存率（87.3%）较低。神经损伤与Shamblin分级相关;主要不良事件和神经损伤均与病理性纤维化相关。与CCBT相比，FCBT易于增加复发、转移、主要不良事件和神经损伤风险。建议FCBT患者早期手术切除，常规切除周围异常淋巴结，并密切临床监测。
To compare the surgical outcomes of carotid body tumor (CBT) with or without pathological fibrosis, and evaluate the associated factors of fibrous CBT (FCBT). Paraffin-embedded tissues of 236 patients with unilateral CBTs at our center were retrospectively reviewed from January 2008 to May 2020. Based on the pathologic features, CBTs were divided into FCBT and conventional CBT (CCBT) groups. The clinical data and surgical outcomes of the two groups were compared. Of 236 patients, 53 had FCBT and 183 had CCBT. FCBTs showed higher vascular invasion (24.53%), marked pleomorphism (22.64%), internal carotid artery reconstruction (37.74%), estimated blood loss (559.62 cm3), and postoperative nerve injury (49.06%), with lower 10-year recurrence- (89.2%) and major adverse event-free survival (87.3%) compared to CCBTs. Nerve injury was correlated with the Shamblin grade; major adverse events and nerve injury were both correlated with pathological fibrosis. Compared with CCBT, FCBT is prone to increased recurrence, metastasis, major adverse events, and nerve injury risk. Early surgical resection, routine excision of surrounding abnormal lymph nodes, and closer clinical surveillance in FCBT patients are recommended.
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影响因子：
9
作者：
Ellis RJ;Patel D;Prodanov T;Nilubol N;Pacak K;Kebebew E
通讯作者：
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影响因子：
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影响因子：
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作者：
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