The effects of chromatin organization on variation in mutation rates in the genome.
The effects of chromatin organization on variation in mutation rates in the genome.
复制标题
染色质组织对基因组突变率变化的影响。
DOI：
10.1038/nrg3890
复制
发表时间：
2015-04
期刊：
影响因子：
--
通讯作者：
Hardison RC
中科院分区：
文献类型：
--
作者：
Makova KD;Hardison RC
局部突变率的变化可以影响基因的进化及其在正常细胞和癌细胞中的功能。通过解析不同类型的突变，将有助于破译这种变异的分子决定因素，因为它们在区域偏好和与基因组特征的关联方面有所不同。染色质组织有助于区域变异的突变率，但不同的突变类型。在生殖系突变和体细胞突变中，碱基替换在闭合染色质区域中更丰富，这可能反映了复制后期的错误积累。相反，具有非常高水平的插入缺失和置换的独特突变状态在开放染色质区域中富集。这些关联阐明了DNA的核苷酸序列及其动态包装成c染色质之间复杂的相互作用，它们对当前的生物医学研究具有重要意义。本文综述了最近的研究显示染色质状态和突变率之间的关联，包括生殖系和体细胞（特别是癌症）突变的成对和多变量调查。
The variation in local rates of mutations can affect both the evolution of genes and their function in normal and cancer cells. Deciphering the molecular determinants of this variation will be aided by resolving distinct types of mutation, since they differ in regional preferences and in associations with genomic features. Chromatin organization contributes to regional variation in mutation rate, but differently among mutation types. In both germ-line mutations and somatic mutations, base substitutions are more abundant in regions of closed chromatin, perhaps reflecting error accumulation late in replication. In contrast, a distinctive mutational state with very high levels of indels and substitutions is enriched in regions of open chromatin. These associations illuminate an intricate interplay between the nucleotide sequence of DNA and its dynamic packaging into c inhromatin, and they have important implications for current biomedical research. This review focuses on the recent studies showing associations between chromatin state and mutation rates, including pairwise and multivariate investigations of germ-line and somatic (particularly cancer) mutations.
H2A.Z 核小体定位对果蝇基因组的遗传变异没有影响
影响因子：
3.7
作者：
Tang Y;Dong S;Cao X;Zhou Q;Ding G;Jiang C
通讯作者：
Jiang C