Neonatal Cytokine Profile in the Airway Mucosal Lining Fluid Is Skewed by Maternal Atopy
Neonatal Cytokine Profile in the Airway Mucosal Lining Fluid Is Skewed by Maternal Atopy
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DOI：
10.1164/rccm.201108-1471oc
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发表时间：
2012-02-01
影响因子：
24.7
通讯作者：
Bisgaard, Hans
中科院分区：
文献类型：
--
作者：
Folsgaard, Nilofar V.;Chawes, Bo L.;Bisgaard, Hans
原理：来自母亲或父亲的遗传可能对复杂疾病（如特应性）产生不同的影响。母源性特应性比父源性特应性对子代发生特应性有更强的危险性。我们假设母亲和父亲的特应性对健康新生儿上呼吸道粘膜衬里液中细胞因子和趋化因子有不同的印迹。目的：研究父母的特应性对健康新生儿上呼吸道粘膜衬里液中细胞因子和趋化因子的印迹。对来自哥本哈根儿童哮喘前瞻性研究（COPSAC）的309名新生儿的鼻粘膜衬里液中的18种细胞因子和趋化因子进行了定量分析测量和主要结果：母亲，而不是父亲，特应性状态（哮喘、花粉热或湿疹伴或不伴致敏）与主成分分析评估的所有18种介质的普遍下调相关（总体P = 0.015）。结论：在无症状新生儿中，母亲的特应性而非父亲的特应性表现出与受抑制的粘膜细胞因子和趋化因子特征的强烈联系，表明在子宫内或围产期的母体环境中留下印记。
Rationale: Heredity from mother or father may impact differently in complex diseases, such as atopy. Maternal atopy is a stronger risk factor than paternal atopy for the development of atopy in the offspring. We hypothesized that mother's and father's atopy would have a differential imprinting on the cytokines and chemokines in the upper airway mucosal lining fluid of healthy neonates.Objectives: To study parental atopic imprinting on the cytokines and chemokines in the upper airway mucosal lining fluid of healthy neonates.Methods: Eighteen cytokines and chemokines were quantified in nasal mucosal lining fluid in 309 neonates from the novel unselected Copenhagen Prospective Study on Asthma in Childhood (COPSAC) birth cohort.Measurements and Main Results: Maternal, but not paternal, atopic status (asthma, hay fever, or eczema with or without sensitization) was associated with general down-regulation of all 18 mediators assessed by principal component analysis (overall P = 0.015).Conclusions: Maternal atopy, but not paternal atopy, showed a strong linkage with a suppressed mucosal cytokine and chemokine signature in asymptomatic neonates, suggesting imprinting by the maternal milieu in utero or perinatal life.