Iop Publishing Journal of Micromechanics and Microengineering a Monolithically Fabricated Gas Chromatography Separation Column with an Integrated High Sensitivity Thermal Conductivity Detector
Iop Publishing Journal of Micromechanics and Microengineering a Monolithically Fabricated Gas Chromatography Separation Column with an Integrated High Sensitivity Thermal Conductivity Detector
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发表时间：
2010
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通讯作者：
B. Kaanta;Hua Chen;Xin Zhang
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作者：
B. Kaanta;Hua Chen;Xin Zhang
高灵敏度检测器与气相色谱（GC）分离柱的单片集成与传统色谱系统的分立组件相比产生了许多潜在的优点。在小型化高速GC系统中，组件互连可能导致检测和分析期间的关键错误和保真度损失。单片集成器件将消除创建氦密封互连的需要，这是庞大的和劳动密集型的。此外，批量制造集成设备，不再需要昂贵和脆弱的检测器，可以通过规模经济降低微型GC系统的成本。我们提出了一个整体式气相色谱分离柱和检测器的设计，制造和操作。我们的装置能够在30秒内分离氮气、甲烷和二氧化碳。这种装置集成方法可以应用于为专门应用设计的现有丰富的柱几何形状和化学性质。
The monolithic integration of a high sensitivity detector with a gas chromatography (GC) separation column creates many potential advantages over the discrete components of a traditional chromatography system. In miniaturized high-speed GC systems, component interconnections can cause crucial errors and loss of fidelity during detection and analysis. A monolithically integrated device would eliminate the need to create helium-tight interconnections, which are bulky and labor intensive. Additionally, batch fabrication of integrated devices that no longer require expensive and fragile detectors can decrease the cost of micro GC systems through economies of scale. We present the design, fabrication and operation of a monolithic GC separation column and detector. Our device is able to separate nitrogen, methane and carbon dioxide within 30 s. This method of device integration could be applied to the existing wealth of column geometries and chemistries designed for specialized applications.