Current trends in community-acquired methicillin-resistant Staphylococcus aureus at a tertiary care pediatric facility
Current trends in community-acquired methicillin-resistant Staphylococcus aureus at a tertiary care pediatric facility
复制标题
DOI：
10.1097/00006454-200012000-00009
复制
发表时间：
2000-12-01
影响因子：
3.6
通讯作者：
Daum, RS
中科院分区：
文献类型：
--
作者：
Hussain, FM;Boyle-Vavra, S;Daum, RS
背景社区获得性耐甲氧西林金黄色葡萄球菌（MRSA）感染的患病率在芝加哥大学儿童医院（UCCH）从1988年至1990年的10/10万住院患者增加到1993年至1995年的259/10万住院患者。由于这种增加可能代表了一次发生或有限的疾病爆发，我们更新了我们以前在1998年和1999年在UCCH的观察，看看这种趋势是否继续下去。前瞻性观察研究。在1年的研究期间，23名住院儿童有MRSA分离株。10个是社区获得的，平均分布在有易感风险因素的儿童和没有易感风险因素的儿童之间。社区获得性MRSA的总体患病率为每10万例住院患者中有208例。10个社区获得性MRSA分离株中有7个对克林霉素敏感。皮肤和软组织感染在社区获得性MRSA分离的儿童中占主导地位。10个社区获得的MRSA分离株的脉冲场凝胶电泳显示8种不同的模式;这些数据表明，多个克隆在UCCH循环。MRSA不再局限于有确定危险因素的儿童。社区获得性MRSA的患病率在儿童中没有确定的危险因素是高的，在我们的机构。
Background. The prevalence of community-acquired methicillin-resistant Staphylococcus aureus (MRSA) infections increased at the University of Chicago Children's Hospital (UCCH) from 10 per 100 000 admissions from 1988 to 1990 to 259 per 100 000 admissions from 1993 to 1995. Because this increase may have represented a one time occurrence or a limited disease outbreak, we updated our previous observations at UCCH in 1998 and 1999 to see whether this trend had continued.Design. Prospective observational study.Results. Twenty-three hospitalized children had an MRSA isolate during the 1-year study period. Ten were community-acquired, equally distributed between children with predisposing risk factors and those without. The overall prevalence of community-acquired MRSA was 208 per 100 000 admissions. Seven of the 10 community-acquired MRSA isolates were susceptible to clindamycin. Skin and soft tissue infections predominated among the children with a community-acquired MRSA isolate. Pulsed field gel electrophoresis of the 10 community-acquired MRSA isolates revealed 8 distinct patterns; these data suggest that multiple clones were circulating at UCCHConclusion. MRSA are no longer confined to children with established risk factors. The prevalence of community-acquired MRSA among children without identified risk factors is high in our institution.