Differential antinociceptive effects of spinal opioids on foot withdrawal responses evoked by C fibre or Aδ nociceptor activation
Differential antinociceptive effects of spinal opioids on foot withdrawal responses evoked by C fibre or Aδ nociceptor activation
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脊髓阿片类药物对 C 纤维或 Aδ 伤害感受器激活引起的足退缩反应的不同抗伤害作用
DOI：
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发表时间：
1997
影响因子：
7.3
通讯作者：
D. Yeomans
中科院分区：
文献类型：
--
作者：
Y. Lu;V. Pirec;D. Yeomans
鞘内应用 μ、δ 和 κ 阿片类药物可减弱多项动物伤害感受测试中的反应。然而，这些阿片类药物的效力因使用的测试而异。造成这些差异的一个因素是不同类型的伤害性刺激激活不同类型的伤害感受器，这些类型可能对阿片类药物抑制的敏感性不同。为了检验这一假设，我们使用了最近开发的行为测试，该测试可以对有髓鞘 (Aδ) 和无髓鞘 C 热伤害感受器激活引起的伤害感受进行差异评估。施用 κ 选择性激动剂对这两种类型的反应均无效。 δ1 药物对 C 纤维介导的反应比对 Aδ 介导的反应稍微更有效。鞘内注射 μ 和 δ2 药物对 Aδ 和 C 伤害感受器介导的反应均具有抗伤害作用。然而，与 δ1 效应不同，μ 和 δ2 药物的剂量反应曲线对于 Aδ 来说明显比 C 纤维介导的反应更陡，这可能表明药物作用于这 2 种反应类型的机制存在差异。
Intrathecal application of μ, δ, and κ opioids attenuate responses on several tests of animal nociception. However, the potency of these opioids differ depending on which tests were used. One factor contributing to these discrepancies is that different types of noxious stimuli activate different sets of nociceptor types, which may be differentially sensitive to opiate inhibition. To examine this hypothesis, we used a recently developed behavioural test which allows for differential assessment of nociception evoked by the activation of myelinated (Aδ) and unmyelinated C thermonociceptors. Administration of a κ‐selective agonist was ineffective on either type of response. δ1 drugs were slightly more potent on C fibre‐mediated responses than on Aδ‐mediated responses. Intrathecal μ and δ2 drugs were antinociceptive on both Aδ and C nociceptor‐mediated responses. However, unlike the δ1 effects, the dose‐response curves for μ and δ2 drugs were significantly more steep for Aδ than for C fibre‐mediated responses, potentially indicating differences in the mechanisms by which the drugs act on these 2 response types.
DOI：
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发表时间：
1994-02
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
P. Stewart;Donna L. Hammond
通讯作者：
P. Stewart;Donna L. Hammond
大鼠脊髓中 δ 阿片受体亚型的证据：鞘内注射 naltriben、环 [D-Pen2、D-Pen5] 脑啡肽和 [D-Ala2、Glu4]deltorphin 的研究。
DOI：
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发表时间：
1993
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Stewart,PE;Hammond,DL
通讯作者：
Hammond,DL
DOI：
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发表时间：
1984
期刊：
The Journal of pharmacology and experimental therapeutics
影响因子：
--
作者：
Schmauss,C;Yaksh,TL
通讯作者：
Yaksh,TL