Auto-aggregation in zoospores of Phytophthora infestans: the cooperative roles of bioconvection and chemotaxis.
Auto-aggregation in zoospores of Phytophthora infestans: the cooperative roles of bioconvection and chemotaxis.
复制标题
致病疫霉游动孢子中的自动聚集：生物对流和趋化性的协同作用。
DOI：
10.1098/rsif.2014.0017
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Savory AI
中科院分区：
文献类型：
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作者：
Savory AI
致病疫霉是一种极具破坏性的植物病原菌。这是19世纪臭名昭著的爱尔兰马铃薯饥荒的原因，至今仍是一个重大的全球问题，每年的相关费用估计为30亿美元。这种病原体成功的关键是被称为游动孢子的自由游动细胞的扩散。游动孢子行为的一个知之甚少的方面是自动聚集-自发形成大规模的细胞密度模式。目前相互竞争的假说表明，这些模式是由两种不同的机制之一形成的：趋化性和生物对流。在本文中，我们提出了数学和实验结果，共同提供了强有力的证据，自动聚集只能从这些机制的组合，每个有一个独特的，时间分离的作用。更好地了解潜在的感染机制。从长远来看，对害虫和潜在的其他Phytophthoraspecies的控制将导致预防性治疗的进步，从而可能大大节省社会经济成本。
Phytophthora infestansis a highly destructive plant pathogen. It was the cause of the infamous Irish potato famine in the nineteenth century and remains to this day a significant global problem with associated costs estimated at $3 billion annually. Key to the success of this pathogen is the dispersal of free-swimming cells called zoospores. A poorly understood aspect of zoospore behaviour isauto-aggregation—the spontaneous formation of large-scale patterns in cell density. Current competing hypotheses suggest that these patterns are formed by one of two distinct mechanisms: chemotaxis and bioconvection. In this paper, we present mathematical and experimental results that together provide strong evidence that auto-aggregation can only result from a combination of these mechanisms, each having a distinct, time-separated role. A better understanding of the underlying infection mechanisms ofP. infestansand potentially otherPhytophthoraspecies will in the longer term lead to advances in preventative treatment and thus potentially significant savings in socio-economic costs.