The neuronal primary cilium--an extrasynaptic signaling device.
The neuronal primary cilium--an extrasynaptic signaling device.
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神经元初级纤毛——一种突触外信号装置。
DOI：
10.1016/j.cellsig.2003.12.002
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发表时间：
2004
影响因子：
4.8
通讯作者：
J. Whitfield
中科院分区：
文献类型：
--
作者：
J. Whitfield
中枢神经系统中的许多神经元（但可能是大多数神经元）都有一个不动的“初级”纤毛，它像天线或手指一样从细胞中心体的一对中心粒延伸到细胞外空间。自从100多年前被发现以来，这些细胞器要么被认为是过去时代的无功能遗物，要么经常被忽视。然而，人们早就知道视网膜视杆和视锥的承载感光器的外段是修饰的初级纤毛，并且最近发现肾细胞的初级纤毛是敏感的流量计，其失效导致多囊肾病。最近的研究表明，生长抑素Sst 3受体和5-羟色胺5-HT 6受体选择性地分布于大鼠脑内不同部位的神经元上。这些被选择性接受的神经元初级纤毛很可能会成为细胞信号传导装置家族的先驱，这些细胞信号传导装置通过缝隙连接和传统的化学突触将信号发送到自己的细胞和相邻的细胞中，从而帮助驱动各种大脑功能。
Many, but likely most, neurons in the central nervous system have a nonmotile “primary” cilium extending like an antenna or finger from one of the pair of centrioles in the cell's centrosome into the extracellular space. Since their discovery over 100 years ago, these organelles have been either dismissed as functionless relicts of a bygone era or more often simply ignored. However, it has long been known that the photoreceptor-bearing outer segments of retinal rods and cones are modified primary cilia and it has recently been found that kidney cells' primary cilia are sensitive flowmeters the disabling of which causes polycystic kidney disease. It has also been recently shown that somatostatin sst3 receptors and serotonin 5-HT6receptors are selectively sited on neurons in various parts of the rat brain. It seems likely that these selectively receptored neuronal primary cilia will turn out to be the forerunners of a family of cell-signaling devices that help drive various brain functions by sending signals into their own cells and into adjacent cells through gap junctions and via conventional chemical synapses.
影响因子：
3.3
作者：
Perrone, CA;Tritschler, D;Porter, ME
通讯作者：
Porter, ME