Interhemispheric connections of the ventral premotor cortex in a new world primate
Interhemispheric connections of the ventral premotor cortex in a new world primate
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DOI：
10.1002/cne.21531
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发表时间：
2007-12-20
影响因子：
2.5
通讯作者：
Nudo, Randolph J.
中科院分区：
文献类型：
--
作者：
Dancause, Numa;Barbay, Scott;Nudo, Randolph J.
本研究描述了松鼠猴腹侧运动前皮层（PMv）远侧前肢表征（DFL）的半球间联系模式。我们的目标是定性和定量地描述PMV与对侧皮质区的联系。皮质内微刺激技术（ICMS）引导神经束示踪剂生物素化葡聚糖胺或固蓝注射到PMv DFL。我们将PMv的半球间联系分为三组。主要的联系被发现在对侧PMv和补充运动区（SMA）。在初级运动皮层的吻侧部分、紧邻PMv吻侧和腹侧的额叶区（FR）、扣带运动区（CMA）和背侧运动前皮层（PMd）中发现了中间半球间连接。在前盖（AO）、后盖/下顶叶皮质（PO/IP）和后顶叶皮质（PP）中发现了不一致的轻微连接，这些区域始终显示出与同侧半球PMv的连接。病例内比较显示，PMv与对侧SMA和PMd的连接百分比高于PMv与同侧半球这些区域的连接百分比; PMv与对侧M1吻侧、FR、AO和初级体感皮层的连接百分比低于PMv与同侧半球这些区域的连接百分比。这些研究增加了我们对PMV的半球间连接模式的认识。它们有助于提供一个解剖学基础，了解PMV的手和大脑半球间的相互作用，可能是背后的协调himanual运动的运动控制的作用。
This study describes the pattern of interhemispheric connections of the ventral premotor cortex (PMv) distal forelimb representation (DFL) in squirrel monkeys. Our objectives were to describe qualitatively and quantitatively the connections of PMv with contralateral cortical areas. Intracortical microstimulation techniques (ICMS) guided the injection of the neuronal tract tracers biotinylated dextran amine or Fast blue into PMv DFL. We classified the interhemispheric connections of PMv into three groups. Major connections were found in the contralateral PMv and supplementary motor area (SMA). Intermediate interhemispheric connections were found in the rostral portion of the primary motor cortex, the frontal area immediately rostral and ventral to PMv (FR), cingulate motor areas (CMAs), and dorsal premotor cortex (PMd). Minor connections were found inconsistently across cases in the anterior operculum (AO), posterior operculum/inferior parietal cortex (PO/IP), and posterior parietal cortex (PP), areas that consistently show connections with PMv in the ipsilateral hemisphere. Within-case comparisons revealed that the percentage of PMv connections with contralateral SMA and PMd are higher than the percentage of PMv connections with these areas in the ipsilateral hemisphere; percentages of PMv connections with contralateral M1 rostral, FR, AO, and the primary somatosensory cortex are lower than percentages of PMv connections with these areas in the ipsilateral hemisphere. These studies increase our knowledge of the pattern of interhemispheric connection of PMv. They help to provide an anatomical foundation for understanding PMv's role in motor control of the hand and interhemispheric interactions that may underlie the coordination of himanual movements.