A genetic propensity to high factor VII is not associated with the risk of myocardial infarction in men
A genetic propensity to high factor VII is not associated with the risk of myocardial infarction in men
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DOI：
10.1055/s-0037-1615188
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发表时间：
1998-08-01
影响因子：
6.7
通讯作者：
Rosendaal, FR
中科院分区：
文献类型：
--
作者：
Doggen, CJM;Cats, VM;Rosendaal, FR
几项研究通过测量血浆中因子VII水平来研究因子VII与冠状动脉疾病之间的关系，有些研究发现高水平与疾病之间存在关联。这遭受了关于高因子VII水平的因果关系的解释问题，因为因子VII水平可能受到致动脉粥样硬化风险因素的影响，并且可能由于动脉粥样硬化而升高。我们在一项包括560例病例和644例对照的大型病例对照研究中调查了与因子VII水平相关的遗传变异（（353）Arg-->Gln）与心肌梗死之间的关系。携带（353）Arg-Arg基因型的个体似乎具有较低的心肌梗死风险（优势比0.80 [95%置信区间0.60-1.06]）。在这项研究中，我们证实了529名（353）Arg等位基因纯合子男性的凝血因子VII抗原和活性水平高于115名（353）Gln等位基因携带者（高出约20%）。我们的结果表明，高凝血因子VII水平的遗传倾向与心肌梗死的风险无关。由于我们证实了（353）Arg-Arg基因型与较高的因子VII水平相关，我们得出结论，高水平的因子VII不是心肌梗死的决定因素。
Several studies have examined the relation between factor VII and coronary artery disease by measuring factor VII levels in plasma and some found an association between high levels and disease. This suffers problems of interpretation concerning the causality of high factor VII levels, because factor VII levels may be affected by atherogenic risk factors and may become elevated as a consequence of atherosclerosis. We investigated the association between a genetic variant ((353)Arg-->Gln), shown to be related to factor VII levels, and myocardial infarction in a large case-control study, including 560 cases and 644 controls. Individuals carrying the (353)Arg-Arg genotype seemed to have a lower risk of myocardial infarction (odds ratio 0.80 [95% confidence interval 0.60-1.06]). In this study, we confirmed higher factor VII antigen and activity level in 529 men homozygous for the (353)Arg allele compared with 115 men carriers of the (353)Gln allele (around 20% higher).Our results indicate that a genetic propensity to high factor VII levels is not associated with the risk of myocardial infarction. Since we confirmed the association of the (353)Arg-Arg genotype with higher factor VII levels, we conclude that high levels of factor VII are not a causal determinant of myocardial infarction.