Astrocyte-induced modulation of synaptic transmission
Astrocyte-induced modulation of synaptic transmission
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DOI：
10.1139/cjpp-77-9-699
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发表时间：
1999-09-01
影响因子：
2.1
通讯作者：
Haydon, PG
中科院分区：
文献类型：
--
作者：
Araque, A;Sanzgiri, RP;Haydon, PG
星形胶质细胞仅仅为神经元提供结构和营养支持的想法受到了最近证据的挑战，这些证据表明星形胶质细胞表现出一种基于细胞内Ca 2+变化和细胞间Ca 2+波的兴奋性和通信形式，这可以由神经元活动启动。这些星形胶质细胞Ca2+的变化现在已被证明可以诱导谷氨酸依赖性Ca2+升高，并减缓神经元的内向电流。最近，已经证明，培养的海马神经元之间的突触传递可以直接由星形胶质细胞调节。我们已经报道了星形胶质细胞刺激可以增加微小突触电流的频率。此外，我们还表明，在星形胶质细胞的细胞内Ca 2+的升高诱导减少兴奋性和抑制性诱发的突触传递通过激活选择性突触前代谢型谷氨酸受体。
The idea that astrocytes simply provide structural and trophic support to neurons has been challenged by recent evidence demonstrating that astrocytes exhibit a form of excitability and communication based on intracellular Ca2+ variations and intercellular Ca2+ waves, which can be initiated by neuronal activity. These astrocyte Ca2+ variations have now been shown to induce glutamate-dependent Ca2+ elevations and slow inward currents in neurons. More recently, it has been demonstrated that synaptic transmission between cultured hippocampal neurons can be directly modulated by astrocytes. We have reported that astrocyte stimulation can increase the frequency of miniature synaptic currents. Furthermore, we also have demonstrated that an elevation in the intracellular Ca2+ in astrocytes induces a reduction in both excitatory and inhibitory evoked synaptic transmission through the activation of selective presynaptic metabotropic glutamate receptors.