Human IgG and IgA responses to COVID-19 mRNA vaccines.
Human IgG and IgA responses to COVID-19 mRNA vaccines.
复制标题
DOI：
10.1371/journal.pone.0249499
复制
发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Redlich CA
中科院分区：
文献类型：
--
作者：
Wisnewski AV;Campillo Luna J;Redlich CA
感染引发的SARS-CoV-2刺突抗原特异性IgG和IgA介导病毒中和，可能是自然免疫的重要组成部分，然而，关于疫苗诱导反应的信息有限。我们连续测定了4例受试者接种后145天血清中COVID-19 mRNA疫苗诱导的IgG和IgA。刺突抗原特异性IgG水平呈指数级上升，并在初始疫苗剂量后21天达到稳定。在第二次接种疫苗后，IgG水平进一步升高，约在7-10天后达到最大值，并在额外的100天随访期间保持升高（平均峰值水平为58%）。COVID-19 mRNA疫苗可诱导刺突抗原特异性IgA，其诱导动力学和达到峰值水平的时间相似，但在第一次和第二次疫苗剂量后血清水平下降更快（第二次疫苗剂量后100天内达到峰值水平<18%）。这些数据表明，COVID-19 mRNA疫苗可有效诱导刺突抗原特异性IgG和IgA，并强调其在血清中的持久性存在显著差异。
SARS-CoV-2 spike antigen-specific IgG and IgA elicited by infection mediate viral neutralization and are likely an important component of natural immunity, however, limited information exists on vaccine induced responses. We measured COVID-19 mRNA vaccine induced IgG and IgA in serum serially, up to 145 days post vaccination in 4 subjects. Spike antigen-specific IgG levels rose exponentially and plateaued 21 days after the initial vaccine dose. After the second vaccine dose IgG levels increased further, reaching a maximum approximately 7–10 days later, and remained elevated (average of 58% peak levels) during the additional >100 day follow up period. COVID-19 mRNA vaccination elicited spike antigen-specific IgA with similar kinetics of induction and time to peak levels, but more rapid decline in serum levels following both the 1st and 2nd vaccine doses (<18% peak levels within 100 days of the 2nd shot). The data demonstrate COVID-19 mRNA vaccines effectively induce spike antigen specific IgG and IgA and highlight marked differences in their persistence in serum.