Diabetes Mellitus: Is It Protective against Aortic Root Dilatation?
Diabetes Mellitus: Is It Protective against Aortic Root Dilatation?
复制标题
糖尿病：它能预防主动脉根部扩张吗？
DOI：
10.1159/000142944
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发表时间：
2009-01-01
期刊：
影响因子：
1.9
通讯作者：
Peng, Xiao-Hui
中科院分区：
文献类型：
--
作者：
Chen, Xiao-Feng;Wang, Jian-An;Peng, Xiao-Hui
目的：有证据表明糖尿病与腹主动脉瘤和主动脉直径呈负相关。然而，关于糖尿病和主动脉根部直径之间的关系的信息很少。方法：对109例2型糖尿病患者进行研究。用二维超声心动图测量主动脉瓣环处的主动脉根、主动脉窦、窦管交界处和升主动脉近端。将测量的平均值与218名年龄和性别匹配的无糖尿病患者进行比较。还比较了两组之间的主动脉瓣返流患病率。结果：糖尿病患者主动脉根部平均直径明显小于非糖尿病患者（p < 0.05）。非糖尿病受试者的主动脉根部扩张患病率显著高于糖尿病患者（9.63 vs. 2.75%; p = 0.025）。在多变量回归模型中，糖尿病是所有测量部位主动脉根部大小的显著负性决定因素。非糖尿病受试者的主动脉瓣返流患病率倾向于高于糖尿病受试者（11 vs. 18.8%）;然而，差异未达到统计学显著性（p = 0.071）。结论：糖尿病患者的主动脉根部尺寸明显小于非糖尿病患者。
Objectives: There is evidence of a negative association between diabetes and both abdominal aortic aneurysm and aortic diameter. However, little information is available on the relation between diabetes and aortic root diameter. Methods: We studied 109 patients with type 2 diabetes. Two-dimensional echocardiography was used to measure the aortic root at the aortic annulus, the sinus of Valsalva, the sinotubular junction and the proximal part of the ascending aorta. Measured mean values were compared with 218 age- and sex-matched patients without diabetes. A comparison of the prevalence of aortic regurgitation between the 2 groups was also performed. Results: In patients with diabetes, the mean aortic root dimensions were significantly smaller than in nondiabetic patients (p < 0.05). The prevalence of aortic root dilatation was significantly higher in nondiabetic subjects than in patients with diabetes (9.63 vs. 2.75%; p = 0.025). In the multivariable regression model, diabetes was a significant negative determinant of aortic root size at all measured sites. The prevalence of aortic regurgitation tended to be higher in nondiabetic subjects than in diabetic participants (11 vs. 18.8%); however, the difference did not achieve statistical significance (p = 0.071). Conclusions: In patients with diabetes, the aortic root dimension is significantly smaller than in patients without diabetes.