The hypoxia-inducible transcription factor pathway regulates oxygen sensing in the simplest animal, Trichoplax adhaerens
The hypoxia-inducible transcription factor pathway regulates oxygen sensing in the simplest animal, Trichoplax adhaerens
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DOI：
10.1038/embor.2010.170
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发表时间：
2011-01-01
期刊：
影响因子：
7.7
通讯作者：
Schofield, Christopher J.
中科院分区：
文献类型：
--
作者：
Loenarz, Christoph;Coleman, Mathew L.;Schofield, Christopher J.
人类的缺氧反应是由缺氧诱导转录因子（HIF）介导的，脯氨酰羟化酶（PHDs）作为氧传感组件。HIF系统的进化起源以前一直不清楚。我们在最简单的动物--粘毛藻中证明了一个功能性的HIF系统：T.粘附素包括糖酵解和代谢酶，表明HIF在基础多细胞动物适应波动的氧水平中的作用。对T. adhaerens PHD和跨物种互补分析揭示了保守的氧传感机制。跨基因组分析合理化HIF系统组件的相对重要性，并暗示HIF系统可能存在于所有动物，但这是唯一的王国。
The hypoxic response in humans is mediated by the hypoxia-inducible transcription factor (HIF), for which prolyl hydroxylases (PHDs) act as oxygen-sensing components. The evolutionary origins of the HIF system have been previously unclear. We demonstrate a functional HIF system in the simplest animal, Trichoplax adhaerens: HIF targets in T. adhaerens include glycolytic and metabolic enzymes, suggesting a role for HIF in the adaptation of basal multicellular animals to fluctuating oxygen levels. Characterization of the T. adhaerens PHDs and cross-species complementation assays reveal a conserved oxygen-sensing mechanism. Cross-genomic analyses rationalize the relative importance of HIF system components, and imply that the HIF system is likely to be present in all animals, but is unique to this kingdom.