Effect of Zn-DTPA therapy on the maternal transfer of 241Am or 237Pu to young mice.
Effect of Zn-DTPA therapy on the maternal transfer of 241Am or 237Pu to young mice.
复制标题
Zn-DTPA 治疗对 241Am 或 237Pu 母体转移至幼鼠的影响。
DOI：
10.1097/00004032-198509000-00002
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发表时间：
1985
期刊：
影响因子：
2.2
通讯作者：
Burnham,JW
中科院分区：
文献类型：
--
作者：
Lloyd,RD;Jones,CW;Mays,CW;Brammer,TW;Burnham,JW
在怀孕期间暴露于241 Am或237 Pu的新生小鼠，其母亲在分娩前的不同时间接受Zn-DTPA治疗，其放射性低于同样暴露于241 Am或237 Pu的新生小鼠，但母亲未接受Zn-DTPA治疗。母亲服用锌- dtpa后，母亲向未出生婴儿转移的放射性核素没有净增加，无论在给予放射性和脱孔治疗的妊娠阶段如何。在母体暴露于241am后很长时间或不久就怀孕的胎鼠中，给予241am 3天后再给予延长的Zn-DTPA治疗，导致胎鼠放射性含量较低。这些数据表明，通过对怀孕母亲和随后怀孕的女性进行锌- dtpa治疗，可以降低Am和Pu对未出生婴儿的风险。随着核工业中可能怀孕或将来可能怀孕的妇女接触到Am或Pu的可能性越来越大，这一信息可能被证明是重要的。
Newborn mice exposed to 241 Am or 237 Pu during gestation and whose mothers were given Zn-DTPA at various times before parturition contained less radioactivity than comparable newborn mice given identical 241 Am or 237 Pu exposure without Zn-DTPA treatment of the mothers. There was no net increase in radionuclide transfer from mothers to unborn young as a result of maternal administration of Zn-DTPA, regardless of the pregnancy stage during which the radioactivity and decorporation treatments were given. Administration of 241 Am followed after three days by extended Zn-DTPA therapy resulted in lower fetal content of radioactivity in litters conceived long after or soon after maternal exposure to 241 Am. These data indicate that the risk from Am and Pu to unborn young can be reduced by Zn-DTPA treatment of the pregnant mother and of the female who becomes pregnant subsequently. This information may prove to be of significance with the inereasing probability of Am or Pu exposure to women in the nuclear industry who could be pregnant at the time or who may conceive a child in the future.